Detailed information of TA system TA236387

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4030957..4031215
• Replicon: chromosome
• Accession: NZ_CP092532
• Organism: Escherichia coli strain DS566-2

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: MKD45_RS19595
• Protein ID: WP_000809168.1
• Coordinates: 4031063..4031215 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4030957..4031014 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKD45_RS19580	4026786..4028045	-	1260	WP_000494929.1	hypothetical protein	-
MKD45_RS19585	4028174..4029667	-	1494	WP_001774152.1	sulfatase-like hydrolase/transferase	-
MKD45_RS19590	4029687..4030448	-	762	WP_001274832.1	outer membrane protein OmpK	-
-	4030957..4031014	-	58	-	-	Antitoxin
MKD45_RS19595	4031063..4031215	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
MKD45_RS19600	4031320..4032450	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
MKD45_RS19605	4032539..4034455	-	1917	WP_000516135.1	molecular chaperone DnaK	-
MKD45_RS19610	4034827..4035231	+	405	WP_000843687.1	DUF2541 family protein	-
MKD45_RS19615	4035257..4035970	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T236387 WP_000809168.1 NZ_CP092532:4031063-4031215 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T236387 NZ_LR590469:c2438937-2438512 [Yersinia enterocolitica subsp. enterocolitica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTGACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCGCTGTGGTTGGTATTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT236387 NZ_CP092532:c4031014-4030957 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin