Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HTH_XRE |
Location | 3491847..3492526 | Replicon | chromosome |
Accession | NZ_CP092532 | ||
Organism | Escherichia coli strain DS566-2 |
Toxin (Protein)
Gene name | higB | Uniprot ID | S1PK60 |
Locus tag | MKD45_RS17070 | Protein ID | WP_000057523.1 |
Coordinates | 3492224..3492526 (-) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | S1QAY3 |
Locus tag | MKD45_RS17065 | Protein ID | WP_000806442.1 |
Coordinates | 3491847..3492188 (-) | Length | 114 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKD45_RS17055 (3488091) | 3488091..3489023 | - | 933 | WP_001538399.1 | glutaminase A | - |
MKD45_RS17060 (3489285) | 3489285..3491789 | + | 2505 | WP_000083948.1 | copper-exporting P-type ATPase CopA | - |
MKD45_RS17065 (3491847) | 3491847..3492188 | - | 342 | WP_000806442.1 | HigA family addiction module antitoxin | Antitoxin |
MKD45_RS17070 (3492224) | 3492224..3492526 | - | 303 | WP_000057523.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MKD45_RS17075 (3492659) | 3492659..3493453 | + | 795 | WP_001538398.1 | TraB/GumN family protein | - |
MKD45_RS17080 (3493657) | 3493657..3494136 | + | 480 | WP_001538397.1 | Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK | - |
MKD45_RS17085 (3494173) | 3494173..3495825 | - | 1653 | WP_001773867.1 | bifunctional UDP-sugar hydrolase/5'-nucleotidase | - |
MKD45_RS17090 (3496043) | 3496043..3497263 | + | 1221 | WP_001773866.1 | fosmidomycin MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11809.44 Da Isoelectric Point: 10.3980
>T236383 WP_000057523.1 NZ_CP092532:c3492526-3492224 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY
Download Length: 303 bp
>T236383 NZ_LR590469:1206406-1206810 [Yersinia enterocolitica subsp. enterocolitica]
ATGCATAAGTACATGCTCGATACGAATATCGTTATATATGTCATTAAACGCCGGCCTATAGAAGTGTTAGGTCGGTTTAA
CGCTAATGCGGGCAGAATGGTTATTTCTTCCATCACACTGGCTGAGTTATTGCATGGCGTAGAGAAAAGCGCGGCACCTG
AACGCAATTTAAGTGTTGTAGAGGATTTTGTTTCACGTCTTACTGTATTGGATTATGACGATAAAGCCGCAATTCACTAT
GGTTCTATACGTGCGAGTCTGGAGCAAAAAGGCACACCCATCGGTGTTAATGATTTGCATATCGCAGGTCATGCCAGAAG
CACCGGATTGATATTAGTGACCAATAATCGCAAAGAATTTGATCGTGTGCCTGGACTGATTGTCGACAACTGGCTAGGAG
AATAA
ATGCATAAGTACATGCTCGATACGAATATCGTTATATATGTCATTAAACGCCGGCCTATAGAAGTGTTAGGTCGGTTTAA
CGCTAATGCGGGCAGAATGGTTATTTCTTCCATCACACTGGCTGAGTTATTGCATGGCGTAGAGAAAAGCGCGGCACCTG
AACGCAATTTAAGTGTTGTAGAGGATTTTGTTTCACGTCTTACTGTATTGGATTATGACGATAAAGCCGCAATTCACTAT
GGTTCTATACGTGCGAGTCTGGAGCAAAAAGGCACACCCATCGGTGTTAATGATTTGCATATCGCAGGTCATGCCAGAAG
CACCGGATTGATATTAGTGACCAATAATCGCAAAGAATTTGATCGTGTGCCTGGACTGATTGTCGACAACTGGCTAGGAG
AATAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 13171.10 Da Isoelectric Point: 5.7790
>AT236383 WP_000806442.1 NZ_CP092532:c3492188-3491847 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA
Download Length: 342 bp
>AT236383 NZ_LR590469:1206173-1206406 [Yersinia enterocolitica subsp. enterocolitica]
ATGTCACAGGGCACCATTTTTACGAACAACCGTACTCAAAACGTGCGTTTACCGGTGGATATGCGCTTTCCAGAGAATGT
TAAATCAGTGACTGTGAGAGCTGTAGGGAATGAGCGTATCTTGTCACCCGTTGAAAACTCTTGGGATAGCTTTTTCTTCA
GTAGTCCGCGTGTTTCAGACGATTTTCTGACCGAACGCGCAGAACAGCATCAATCAGAGCGTGAGTTATTTTAA
ATGTCACAGGGCACCATTTTTACGAACAACCGTACTCAAAACGTGCGTTTACCGGTGGATATGCGCTTTCCAGAGAATGT
TAAATCAGTGACTGTGAGAGCTGTAGGGAATGAGCGTATCTTGTCACCCGTTGAAAACTCTTGGGATAGCTTTTTCTTCA
GTAGTCCGCGTGTTTCAGACGATTTTCTGACCGAACGCGCAGAACAGCATCAATCAGAGCGTGAGTTATTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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