Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 31322..32033 Replicon plasmid pMFDS1011659
Accession NZ_CP092511
Organism Salmonella enterica subsp. enterica serovar Thompson

Toxin (Protein)


Gene name higB Uniprot ID I2UJZ0
Locus tag MKE90_RS23660 Protein ID WP_000162415.1
Coordinates 31322..31624 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MKE90_RS23665 Protein ID WP_000806445.1
Coordinates 31695..32033 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKE90_RS23630 (MKE90_23625) 26341..26991 - 651 WP_032153356.1 hypothetical protein -
MKE90_RS23635 (MKE90_23630) 27005..27910 - 906 WP_001258014.1 recombination-associated protein RdgC -
MKE90_RS23640 (MKE90_23635) 27970..28623 - 654 WP_271232211.1 baseplate protein -
MKE90_RS23645 (MKE90_23640) 28620..29600 - 981 WP_271232212.1 tail length tape measure protein -
MKE90_RS23650 (MKE90_23645) 29604..30371 - 768 WP_000203290.1 hypothetical protein -
MKE90_RS23655 (MKE90_23650) 30368..31159 - 792 WP_000532305.1 hypothetical protein -
MKE90_RS23660 (MKE90_23655) 31322..31624 + 303 WP_000162415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKE90_RS23665 (MKE90_23660) 31695..32033 + 339 WP_000806445.1 HigA family addiction module antitoxin Antitoxin
MKE90_RS23670 (MKE90_23665) 32090..32275 + 186 Protein_35 hypothetical protein -
MKE90_RS23675 (MKE90_23670) 32312..33040 + 729 WP_000986754.1 hypothetical protein -
MKE90_RS23680 (MKE90_23675) 33074..34267 - 1194 WP_001112633.1 hypothetical protein -
MKE90_RS23685 (MKE90_23680) 34260..34589 - 330 WP_000542383.1 hypothetical protein -
MKE90_RS23690 (MKE90_23685) 34918..35571 - 654 WP_000410952.1 hypothetical protein -
MKE90_RS23695 (MKE90_23690) 35917..36738 + 822 WP_001427910.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92361 92361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11818.56 Da        Isoelectric Point: 9.8739

>T236351 WP_000162415.1 NZ_CP092511:31322-31624 [Salmonella enterica subsp. enterica serovar Thompson]
MTKKINIKDFRDAWLDDFFEFSTPHRKIPPDIHMTLSRKLDIINAATTCKDLRSPPGNRYEELSGKLNGYSSVRVNKQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

>T236351 NZ_LR588408:1911082-1911184 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13049.98 Da        Isoelectric Point: 6.4754

>AT236351 WP_000806445.1 NZ_CP092511:31695-32033 [Salmonella enterica subsp. enterica serovar Thompson]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRINTAEKFISQRNLNKKAA

Download         Length: 339 bp

>AT236351 NZ_LR588408:c1911191-1911046 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A631VBQ3

Antitoxin

Source ID Structure

References