Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4631287..4632041 | Replicon | chromosome |
| Accession | NZ_CP092510 | ||
| Organism | Salmonella enterica subsp. enterica serovar Thompson | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5I4V816 |
| Locus tag | MKE90_RS22560 | Protein ID | WP_017465947.1 |
| Coordinates | 4631287..4631598 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MKE90_RS22565 | Protein ID | WP_017465948.1 |
| Coordinates | 4631595..4632041 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKE90_RS22530 (4626945) | 4626945..4627847 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| MKE90_RS22535 (4627844) | 4627844..4628479 | + | 636 | WP_000829028.1 | formate dehydrogenase cytochrome b556 subunit | - |
| MKE90_RS22540 (4628476) | 4628476..4629405 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| MKE90_RS22545 (4629452) | 4629452..4629742 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| MKE90_RS22550 (4629743) | 4629743..4630054 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| MKE90_RS22555 (4630272) | 4630272..4631201 | + | 930 | WP_001127708.1 | alpha/beta hydrolase | - |
| MKE90_RS22560 (4631287) | 4631287..4631598 | + | 312 | WP_017465947.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| MKE90_RS22565 (4631595) | 4631595..4632041 | + | 447 | WP_017465948.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| MKE90_RS22570 (4632056) | 4632056..4632997 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| MKE90_RS22575 (4633042) | 4633042..4633479 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| MKE90_RS22580 (4633476) | 4633476..4634348 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| MKE90_RS22585 (4634342) | 4634342..4634941 | - | 600 | WP_001621364.1 | glucose-1-phosphatase | - |
| MKE90_RS22590 (4635132) | 4635132..4635935 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| MKE90_RS22595 (4635969) | 4635969..4636865 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12384.31 Da Isoelectric Point: 9.2528
>T236350 WP_017465947.1 NZ_CP092510:4631287-4631598 [Salmonella enterica subsp. enterica serovar Thompson]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
>T236350 NZ_LR588408:795511-795921 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16736.06 Da Isoelectric Point: 6.6451
>AT236350 WP_017465948.1 NZ_CP092510:4631595-4632041 [Salmonella enterica subsp. enterica serovar Thompson]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT236350 NZ_LR588408:795264-795530 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|