Detailed information of TA system TA236267

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-sprA1AS/-
• Location: 2488576..2488724
• Replicon: chromosome
• Accession: NZ_CP092478
• Organism: Staphylococcus haemolyticus strain CGMH-SH51

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: MKD39_RS12175
• Protein ID: WP_011276848.1
• Coordinates: 2488576..2488671 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2488689..2488724 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKD39_RS12140 (MKD39_12120)	2484303..2484536	+	234	WP_016931184.1	hypothetical protein	-
MKD39_RS12145 (MKD39_12125)	2484644..2484961	-	318	Protein_2344	IS200/IS605-like element ISSep3 family transposase	-
MKD39_RS12150 (MKD39_12130)	2485786..2485911	+	126	WP_031886468.1	hypothetical protein	-
MKD39_RS12155 (MKD39_12135)	2486515..2487045	+	531	WP_011276845.1	N-acetyltransferase	-
MKD39_RS12160 (MKD39_12140)	2487285..2487668	+	384	WP_011276846.1	effector binding domain-containing protein	-
MKD39_RS12165 (MKD39_12145)	2487807..2488067	+	261	WP_011276847.1	hypothetical protein	-
MKD39_RS12170 (MKD39_12150)	2488133..2488381	+	249	WP_002440480.1	hypothetical protein	-
MKD39_RS12175 (MKD39_12155)	2488576..2488671	+	96	WP_011276848.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2488689..2488724	+	36	-	-	Antitoxin
MKD39_RS12180 (MKD39_12160)	2488865..2489524	+	660	WP_011276849.1	nucleotidyltransferase	-
MKD39_RS12185 (MKD39_12165)	2489770..2490372	+	603	WP_011276850.1	hypothetical protein	-
MKD39_RS12190 (MKD39_12170)	2490732..2491577	-	846	WP_000733283.1	BlaZ family penicillin-hydrolyzing class A beta-lactamase PC1	-
MKD39_RS12195 (MKD39_12175)	2491684..2493441	+	1758	WP_011276042.1	beta-lactam sensor/signal transducer BlaR1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2484641..2484961	320

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3623.38 Da
• Isoelectric Point: 9.5124

>T236267 WP_011276848.1 NZ_CP092478:2488576-2488671 [Staphylococcus haemolyticus]
MLEILVHITTTVISGCIIALFTHWLRNRKDK

Nucleotide

• Length: 96 bp

>T236267 NZ_LR216060:c1694193-1693939 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin

Nucleotide

• Length: 36 bp

>AT236267 NZ_CP092478:2488689-2488724 [Staphylococcus haemolyticus]
TACAACAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin