Detailed information of TA system TA236259

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1304808..1305146
• Replicon: chromosome
• Accession: NZ_CP092475
• Organism: Staphylococcus aureus strain P5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MKD48_RS06920
• Protein ID: WP_011447039.1
• Coordinates: 1304808..1304984 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1304972..1305146 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKD48_RS06890	1300082..1300372	+	291	WP_000179858.1	hypothetical protein	-
MKD48_RS06895	1300388..1302298	+	1911	WP_000429558.1	minor structural protein	-
MKD48_RS06900	1302298..1303764	+	1467	WP_000067127.1	BppU family phage baseplate upper protein	-
MKD48_RS06905	1303764..1304153	+	390	WP_001166596.1	DUF2977 domain-containing protein	-
MKD48_RS06910	1304146..1304310	+	165	WP_000916020.1	XkdX family protein	-
MKD48_RS06915	1304356..1304655	+	300	WP_000466784.1	DUF2951 domain-containing protein	-
MKD48_RS06920	1304808..1304984	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1304972..1305146	-	175	-	-	Antitoxin
MKD48_RS06930	1305196..1305450	+	255	WP_000611512.1	phage holin	-
MKD48_RS06935	1305462..1306217	+	756	WP_000861038.1	CHAP domain-containing protein	-
MKD48_RS06940	1306578..1308482	+	1905	WP_001003363.1	N-6 DNA methylase	-
MKD48_RS06945	1308469..1309479	+	1011	WP_000777019.1	restriction endonuclease subunit S	-
MKD48_RS06950	1309658..1309873	+	216	WP_170267452.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T236259 WP_011447039.1 NZ_CP092475:1304808-1304984 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T236259 NZ_LR215983:132271-132546 [Eubacterium limosum]
TTGGCTGAAAAATATCATGTTGTTTTAACTGAAAAAGCAAAAAAGAGTTTAAAAAAACTTGATAAGCATACAGCGCTTTT
GATTACAGCTTGGTTGAGGAAAAATCTTGAGGGCTGCACCGATCCCTATCAGTACGGCAAGGGCCTCACCGCTAACCGCA
GCGGACAATGGCGCTACCGCATCGGCGATTACCGTCTGGTCTGCGAGATTTCCGAGCAGACGATCACGATTCTGGTTTTA
AATATTGGGCACAGAAAAGAAATTTACAAACATTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT236259 NZ_CP092475:c1305146-1304972 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin