Detailed information of TA system TA236256

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1268181..1268760
• Replicon: chromosome
• Accession: NZ_CP092475
• Organism: Staphylococcus aureus strain P5

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MKD48_RS06670
• Protein ID: WP_001025401.1
• Coordinates: 1268181..1268426 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1268395..1268760 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKD48_RS06620 (1264430)	1264430..1265044	+	615	WP_000191464.1	hypothetical protein	-
MKD48_RS06625 (1265041)	1265041..1265187	-	147	WP_001795334.1	hypothetical protein	-
MKD48_RS06630 (1265224)	1265224..1265406	-	183	WP_000705240.1	hypothetical protein	-
MKD48_RS06635 (1265477)	1265477..1266208	-	732	WP_000511090.1	XRE family transcriptional regulator	-
MKD48_RS06640 (1266360)	1266360..1266572	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
MKD48_RS06645 (1266620)	1266620..1267063	+	444	WP_000435357.1	hypothetical protein	-
MKD48_RS06650 (1267078)	1267078..1267227	+	150	WP_000771849.1	hypothetical protein	-
MKD48_RS06655 (1267268)	1267268..1267480	-	213	WP_000362644.1	hypothetical protein	-
MKD48_RS06660 (1267550)	1267550..1267747	+	198	WP_001148860.1	hypothetical protein	-
MKD48_RS06665 (1267734)	1267734..1268114	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
MKD48_RS06670 (1268181)	1268181..1268426	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MKD48_RS06675 (1268395)	1268395..1268760	-	366	WP_001128433.1	hypothetical protein	Antitoxin
MKD48_RS06680 (1268815)	1268815..1269030	+	216	WP_001097552.1	hypothetical protein	-
MKD48_RS06685 (1269055)	1269055..1269318	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
MKD48_RS06690 (1269331)	1269331..1269492	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
MKD48_RS06695 (1269571)	1269571..1269894	+	324	WP_000175000.1	hypothetical protein	-
MKD48_RS06700 (1269909)	1269909..1270271	+	363	WP_000985986.1	hypothetical protein	-
MKD48_RS06705 (1270268)	1270268..1271434	+	1167	WP_000762534.1	DUF2800 domain-containing protein	-
MKD48_RS06710 (1271460)	1271460..1272014	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T236256 WP_001025401.1 NZ_CP092475:1268181-1268426 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T236256 NZ_LR215973:3581126-3581518 [Nocardia cyriacigeorgica]
ATGCTCTACCTAGACACCAGCGCACTGGTCAAACTGGTCCACCCGGAAGCCGAGACCGACGCACTCTTGCGCTGGCTCGA
GGAACGACCCGACCTGCCCTGGGTGGCGTCCGCTCTCGTCGAGGTCGAACTGGTCCGTGCCGTGCGGATGGCCGAACCAG
CGGACCTCATTCACATCCCCGCCGTTCTCGCACGACTCGACATGGTGGAAATCGATGGCATCGTCCGAGCGAACGCAGCC
GCGATTTCACCGGCAACCGTGCGCAGCCTGGACGCTATACACCTCGCCACAGCTCTCGAACTGGCCACAGACCTCACCGG
CCTGGTCGCATATGACAAGCGCCTGGGCGAGGCTGCCGAAGCCGCCGGATTGACCTGGATCGCACCTCGTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT236256 NZ_CP092475:c1268760-1268395 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin