Detailed information of TA system TA236250

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 782708..783046
• Replicon: chromosome
• Accession: NZ_CP092475
• Organism: Staphylococcus aureus strain P5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MKD48_RS04025
• Protein ID: WP_011447039.1
• Coordinates: 782708..782884 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	782872..783046 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKD48_RS04005	777943..781728	+	3786	WP_000582168.1	phage tail spike protein	-
MKD48_RS04010	781718..781870	+	153	WP_001153681.1	hypothetical protein	-
MKD48_RS04015	781917..782204	+	288	WP_001040261.1	hypothetical protein	-
MKD48_RS04020	782262..782558	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
MKD48_RS04025	782708..782884	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	782872..783046	-	175	-	-	Antitoxin
MKD48_RS04035	783096..783350	+	255	WP_000611512.1	phage holin	-
MKD48_RS04040	783362..784117	+	756	WP_000861039.1	CHAP domain-containing protein	-
MKD48_RS04045	784308..784799	+	492	WP_000919349.1	staphylokinase	-
MKD48_RS04050	785449..785784	+	336	Protein_796	SH3 domain-containing protein	-
MKD48_RS04055	785879..786328	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
MKD48_RS04060	787013..787363	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
MKD48_RS04065	787416..787676	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	730636..787363	56727

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T236250 WP_011447039.1 NZ_CP092475:782708-782884 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T236250 NZ_LR215729:c2393287-2392994 [Pseudomonas marincola]
GTGCCACGATTGATTGTTACTGAAGGCGCGGCGAAGGGCTTGGAGCGTTGCCGGCGATTCCTCTCAGACAAAGATCCGCA
GGTCGCGCGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCATTTC
CAGATCTGCCGGAGCTGCGTGTGCTCATCATCGAATTTGGTGACTCAGGTTACGTAGCGTTGTACCGCTATGAGCGTGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT236250 NZ_CP092475:c783046-782872 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin