Detailed information of TA system TA236244

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 604537..604800
• Replicon: chromosome
• Accession: NZ_CP092475
• Organism: Staphylococcus aureus strain P5

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: -
• Locus tag: MKD48_RS03005
• Protein ID: WP_075583739.1
• Coordinates: 604537..604641 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	604636..604800 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKD48_RS02985	601335..602117	+	783	WP_000908181.1	ABC transporter ATP-binding protein	-
MKD48_RS02990	602185..603042	+	858	WP_000370944.1	HAD family hydrolase	-
MKD48_RS02995	603702..603860	-	159	WP_024928151.1	hypothetical protein	-
MKD48_RS03000	604278..604439	+	162	Protein_591	helix-turn-helix domain-containing protein	-
MKD48_RS03005	604537..604641	+	105	WP_075583739.1	hypothetical protein	Toxin
-	604636..604800	-	165	-	-	Antitoxin
MKD48_RS03015	605156..606247	-	1092	WP_000495678.1	hypothetical protein	-
MKD48_RS03020	606513..607493	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
MKD48_RS03025	607495..607815	-	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MKD48_RS03030	607967..608632	+	666	WP_001024097.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3861.73 Da
• Isoelectric Point: 7.0039

>T236244 WP_075583739.1 NZ_CP092475:604537-604641 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISNQGHKK

Nucleotide

• Length: 105 bp

>T236244 NZ_LR213461:c26070-25921 [Shigella sonnei]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT236244 NZ_CP092475:c604800-604636 [Staphylococcus aureus]
GTAGTAAGTAGAAGTAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCAGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Antitoxin