Detailed information of TA system TA236241

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 317800..317984
• Replicon: chromosome
• Accession: NZ_CP092475
• Organism: Staphylococcus aureus strain P5

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MKD48_RS01505
• Protein ID: WP_000482647.1
• Coordinates: 317800..317907 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	317924..317984 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKD48_RS01480	313165..313638	+	474	WP_000456498.1	GyrI-like domain-containing protein	-
MKD48_RS01485	313761..314972	-	1212	WP_052995981.1	multidrug effflux MFS transporter	-
MKD48_RS01490	315151..315810	-	660	WP_000831298.1	membrane protein	-
MKD48_RS01495	315870..317012	-	1143	WP_001176863.1	glycerate kinase	-
MKD48_RS01500	317280..317666	+	387	WP_000779356.1	flippase GtxA	-
MKD48_RS01505	317800..317907	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	317924..317984	-	61	-	-	Antitoxin
MKD48_RS01510	318667..320430	+	1764	WP_001064811.1	ATP-binding cassette domain-containing protein	-
MKD48_RS01515	320455..322188	+	1734	WP_000486501.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T236241 WP_000482647.1 NZ_CP092475:317800-317907 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T236241 NZ_LR213458:c4074645-4074238 [Shigella sonnei]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT236241 NZ_CP092475:c317984-317924 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin