Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 286167..286690 Replicon chromosome
Accession NZ_CP092475
Organism Staphylococcus aureus strain P5

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MKD48_RS01365 Protein ID WP_000074048.1
Coordinates 286424..286690 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MKD48_RS01360 Protein ID WP_000587616.1
Coordinates 286167..286424 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD48_RS01345 (282664) 282664..283413 - 750 WP_000072439.1 CPBP family lipoprotein N-acylation protein LnsB -
MKD48_RS01350 (283608) 283608..285185 + 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
MKD48_RS01355 (285353) 285353..285808 - 456 WP_000732088.1 DUF1307 domain-containing protein -
MKD48_RS01360 (286167) 286167..286424 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKD48_RS01365 (286424) 286424..286690 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MKD48_RS01370 (287045) 287045..288121 + 1077 WP_001076688.1 M42 family metallopeptidase -
MKD48_RS01375 (288467) 288467..289129 + 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
MKD48_RS01380 (289122) 289122..289898 + 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
MKD48_RS01385 (290292) 290292..291479 + 1188 WP_000026196.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T236240 WP_000074048.1 NZ_CP092475:286424-286690 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T236240 NZ_LR213458:c3944836-3944501 [Shigella sonnei]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT236240 WP_000587616.1 NZ_CP092475:286167-286424 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT236240 NZ_LR213458:c3945084-3944836 [Shigella sonnei]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References