Detailed information of TA system TA236238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1262518..1263032
• Replicon: chromosome
• Accession: NZ_CP092470
• Organism: Bifidobacterium pseudocatenulatum strain Bi-OTA128

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MJ646_RS05400
• Protein ID: WP_055054685.1
• Coordinates: 1262518..1262772 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A3E5ATR4
• Locus tag: MJ646_RS05405
• Protein ID: WP_065440807.1
• Coordinates: 1262772..1263032 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ646_RS05385 (MJ646_05365)	1258800..1260995	+	2196	WP_277715163.1	type IA DNA topoisomerase	-
MJ646_RS05390 (MJ646_05370)	1261419..1262315	+	897	WP_117656661.1	Fic family protein	-
MJ646_RS05395	1262403..1262531	-	129	WP_259297793.1	hypothetical protein	-
MJ646_RS05400 (MJ646_05375)	1262518..1262772	-	255	WP_055054685.1	Txe/YoeB family addiction module toxin	Toxin
MJ646_RS05405 (MJ646_05380)	1262772..1263032	-	261	WP_065440807.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MJ646_RS05410 (MJ646_05385)	1263291..1263563	+	273	WP_277714882.1	hypothetical protein	-
MJ646_RS05415 (MJ646_05390)	1263836..1264153	-	318	WP_065440803.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10013.51 Da
• Isoelectric Point: 7.9920

>T236238 WP_055054685.1 NZ_CP092470:c1262772-1262518 [Bifidobacterium pseudocatenulatum]
IMLRWTDDAWNDYLYWQVQDKKTLKRVNALIRDAMRSPFAGLGKPEPLKWELQGAWSRRIDSANRLVYMIEDGDLCILSV
RDHY

Nucleotide

• Length: 255 bp

>T236238 NZ_LR213458:c3063633-3063382 [Shigella sonnei]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9702.90 Da
• Isoelectric Point: 4.7241

>AT236238 WP_065440807.1 NZ_CP092470:c1263032-1262772 [Bifidobacterium pseudocatenulatum]
MVTAVAYTNFRKDLKSYLRRVNDDADMLLITNKDPGDNVVVMSADDYDSLMETLRVYQNPGLFDKVRRGMAQVRSGSTDS
HDLVGE

Nucleotide

• Length: 261 bp

>AT236238 NZ_LR213458:c3063385-3063131 [Shigella sonnei]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A3E5ATR4