Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4935856..4936455 Replicon chromosome
Accession NZ_CP092466
Organism Citrobacter portucalensis strain Cf7303

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LY264_RS23790 Protein ID WP_048227551.1
Coordinates 4936144..4936455 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LY264_RS23785 Protein ID WP_038635893.1
Coordinates 4935856..4936143 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY264_RS23770 (LY264_23765) 4933352..4934254 + 903 WP_003825273.1 formate dehydrogenase O subunit beta -
LY264_RS23775 (LY264_23770) 4934251..4934886 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
LY264_RS23780 (LY264_23775) 4934883..4935812 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
LY264_RS23785 (LY264_23780) 4935856..4936143 - 288 WP_038635893.1 NadS family protein Antitoxin
LY264_RS23790 (LY264_23785) 4936144..4936455 - 312 WP_048227551.1 hypothetical protein Toxin
LY264_RS23795 (LY264_23790) 4936676..4937584 + 909 WP_048227550.1 alpha/beta hydrolase -
LY264_RS23800 (LY264_23795) 4937649..4937891 + 243 WP_048227549.1 type II toxin-antitoxin system ParD family antitoxin -
LY264_RS23805 (LY264_23800) 4937930..4938172 + 243 WP_240498933.1 type II toxin-antitoxin system RelE/ParE family toxin -
LY264_RS23810 (LY264_23805) 4938178..4939119 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
LY264_RS23815 (LY264_23810) 4939164..4939601 - 438 WP_048227548.1 D-aminoacyl-tRNA deacylase -
LY264_RS23820 (LY264_23815) 4939598..4940470 - 873 WP_008786998.1 virulence factor BrkB family protein -
LY264_RS23825 (LY264_23820) 4940464..4941063 - 600 WP_008786997.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12390.54 Da        Isoelectric Point: 10.2893

>T236235 WP_048227551.1 NZ_CP092466:c4936455-4936144 [Citrobacter portucalensis]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLAIQPDCGDLIQETGGLRKVRWRSRGKGKRSGVRIIYFHQIRKSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNERW

Download         Length: 312 bp

>T236235 NZ_LR213458:2947581-2947688 [Shigella sonnei]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10761.36 Da        Isoelectric Point: 11.1842

>AT236235 WP_038635893.1 NZ_CP092466:c4936143-4935856 [Citrobacter portucalensis]
MDKALFERLTQSMVQMNEIAEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp

>AT236235 NZ_LR213458:c2947524-2947468 [Shigella sonnei]
TCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References