Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2610900..2611462 Replicon chromosome
Accession NZ_CP092466
Organism Citrobacter portucalensis strain Cf7303

Toxin (Protein)


Gene name higB Uniprot ID A0A1C0NXV4
Locus tag LY264_RS12700 Protein ID WP_003833016.1
Coordinates 2611184..2611462 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6H3AUF8
Locus tag LY264_RS12695 Protein ID WP_003833018.1
Coordinates 2610900..2611184 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY264_RS12680 (LY264_12680) 2608595..2609479 + 885 WP_003833024.1 formate dehydrogenase N subunit beta -
LY264_RS12685 (LY264_12685) 2609472..2610128 + 657 WP_003020054.1 formate dehydrogenase-N subunit gamma -
LY264_RS12690 (LY264_12690) 2610258..2610860 + 603 WP_003833020.1 inorganic diphosphatase -
LY264_RS12695 (LY264_12695) 2610900..2611184 - 285 WP_003833018.1 HigA family addiction module antitoxin Antitoxin
LY264_RS12700 (LY264_12700) 2611184..2611462 - 279 WP_003833016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LY264_RS12705 (LY264_12705) 2611683..2613398 - 1716 WP_008784796.1 ABC-F family ATP-binding cassette domain-containing protein -
LY264_RS12710 (LY264_12710) 2613865..2614767 + 903 WP_071692399.1 endonuclease/exonuclease/phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10667.30 Da        Isoelectric Point: 9.8965

>T236228 WP_003833016.1 NZ_CP092466:c2611462-2611184 [Citrobacter portucalensis]
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGERDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T236228 NZ_LR213458:754195-754368 [Shigella sonnei]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.10 Da        Isoelectric Point: 8.8094

>AT236228 WP_003833018.1 NZ_CP092466:c2611184-2610900 [Citrobacter portucalensis]
MKMANHPRPGDIIQEALEELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAEAQ
KSVDISRLRKLAVQ

Download         Length: 285 bp

>AT236228 NZ_LR213458:753871-754167 [Shigella sonnei]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0NXV4

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AUF8

References