Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1783629..1784131 Replicon chromosome
Accession NZ_CP092449
Organism Escherichia coli isolate TKEC21-17

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag MJJ13_RS08510 Protein ID WP_000767831.1
Coordinates 1783877..1784131 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag MJJ13_RS08505 Protein ID WP_001259255.1
Coordinates 1783629..1783880 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJJ13_RS08480 (1778806) 1778806..1779873 - 1068 WP_085448381.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
MJJ13_RS08485 (1779873) 1779873..1780943 - 1071 WP_085448380.1 histidinol-phosphate transaminase -
MJJ13_RS08490 (1780940) 1780940..1782244 - 1305 WP_085448379.1 histidinol dehydrogenase -
MJJ13_RS08495 (1782250) 1782250..1783149 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
MJJ13_RS08500 (1783295) 1783295..1783345 - 51 WP_001364200.1 his operon leader peptide -
MJJ13_RS08505 (1783629) 1783629..1783880 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
MJJ13_RS08510 (1783877) 1783877..1784131 + 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
MJJ13_RS08515 (1784214) 1784214..1785038 + 825 WP_000754737.1 SDR family oxidoreductase -
MJJ13_RS08520 (1785084) 1785084..1786013 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
MJJ13_RS08525 (1786228) 1786228..1786290 + 63 WP_010723108.1 membrane protein YoeI -
MJJ13_RS08530 (1786280) 1786280..1787638 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
MJJ13_RS08535 (1787817) 1787817..1788875 + 1059 WP_000492321.1 thiosulfate utilization transporter TsuA/YeeE -
MJJ13_RS08540 (1788889) 1788889..1789116 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T236131 WP_000767831.1 NZ_CP092449:1783877-1784131 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

>T236131 NZ_LR135372:188654-188920 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT236131 WP_001259255.1 NZ_CP092449:1783629-1783880 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT236131 NZ_LR135372:188391-188654 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References