Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 729379..730072 Replicon chromosome
Accession NZ_CP092449
Organism Escherichia coli isolate TKEC21-17

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MJJ13_RS03635 Protein ID WP_000415584.1
Coordinates 729379..729675 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MJJ13_RS03640 Protein ID WP_000650107.1
Coordinates 729677..730072 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJJ13_RS03600 (724936) 724936..725016 + 81 Protein_708 DUF2645 domain-containing protein -
MJJ13_RS03610 (725787) 725787..726044 + 258 Protein_710 DUF2645 family protein -
MJJ13_RS03615 (726090) 726090..727439 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MJJ13_RS03620 (727436) 727436..728095 - 660 WP_239812931.1 quorum sensing response regulator transcription factor QseB -
MJJ13_RS03625 (728247) 728247..728639 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MJJ13_RS03630 (728692) 728692..729174 + 483 WP_000183505.1 GyrI-like domain-containing protein -
MJJ13_RS03635 (729379) 729379..729675 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MJJ13_RS03640 (729677) 729677..730072 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MJJ13_RS03645 (730205) 730205..731812 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MJJ13_RS03650 (731950) 731950..734208 + 2259 WP_032247867.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T236128 WP_000415584.1 NZ_CP092449:729379-729675 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T236128 NZ_LR135364:499220-499561 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT236128 WP_000650107.1 NZ_CP092449:729677-730072 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT236128 NZ_LR135364:498990-499220 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References