Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2355612..2356129 | Replicon | chromosome |
| Accession | NZ_CP092447 | ||
| Organism | Staphylococcus aureus strain SYN | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | LXM97_RS11470 | Protein ID | WP_000113263.1 |
| Coordinates | 2355612..2355878 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | LXM97_RS11475 | Protein ID | WP_000584499.1 |
| Coordinates | 2355878..2356129 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXM97_RS11440 (LXM97_11440) | 2350872..2351408 | - | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
| LXM97_RS11445 (LXM97_11445) | 2351821..2352645 | - | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| LXM97_RS11450 (LXM97_11450) | 2352849..2353031 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| LXM97_RS11455 (LXM97_11455) | 2353118..2353585 | - | 468 | WP_000153338.1 | SRPBCC domain-containing protein | - |
| LXM97_RS11460 (LXM97_11460) | 2353771..2355318 | - | 1548 | WP_000727757.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| LXM97_RS11465 (LXM97_11465) | 2355506..2355577 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| LXM97_RS11470 (LXM97_11470) | 2355612..2355878 | - | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| LXM97_RS11475 (LXM97_11475) | 2355878..2356129 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LXM97_RS11480 (LXM97_11480) | 2356302..2356393 | - | 92 | Protein_2212 | hypothetical protein | - |
| LXM97_RS11485 (LXM97_11485) | 2356400..2356999 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| LXM97_RS11490 (LXM97_11490) | 2357018..2357380 | - | 363 | WP_000819839.1 | DUF4467 domain-containing protein | - |
| LXM97_RS11495 (LXM97_11495) | 2357635..2358885 | + | 1251 | WP_001012236.1 | FemA/FemB family glycyltransferase FmhA | - |
| LXM97_RS11500 (LXM97_11500) | 2358982..2359713 | - | 732 | WP_000615464.1 | amino acid ABC transporter ATP-binding protein | - |
| LXM97_RS11505 (LXM97_11505) | 2359710..2360429 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T236122 WP_000113263.1 NZ_CP092447:c2355878-2355612 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T236122 NZ_LR135357:c2102125-2101784 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT236122 WP_000584499.1 NZ_CP092447:c2356129-2355878 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT236122 NZ_LR135357:c2102355-2102125 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|