Detailed information of TA system TA236122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2355612..2356129
• Replicon: chromosome
• Accession: NZ_CP092447
• Organism: Staphylococcus aureus strain SYN

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: LXM97_RS11470
• Protein ID: WP_000113263.1
• Coordinates: 2355612..2355878 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: LXM97_RS11475
• Protein ID: WP_000584499.1
• Coordinates: 2355878..2356129 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXM97_RS11440 (LXM97_11440)	2350872..2351408	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
LXM97_RS11445 (LXM97_11445)	2351821..2352645	-	825	WP_000594633.1	formate/nitrite transporter family protein	-
LXM97_RS11450 (LXM97_11450)	2352849..2353031	-	183	WP_000079140.1	hypothetical protein	-
LXM97_RS11455 (LXM97_11455)	2353118..2353585	-	468	WP_000153338.1	SRPBCC domain-containing protein	-
LXM97_RS11460 (LXM97_11460)	2353771..2355318	-	1548	WP_000727757.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
LXM97_RS11465 (LXM97_11465)	2355506..2355577	-	72	WP_223200558.1	hypothetical protein	-
LXM97_RS11470 (LXM97_11470)	2355612..2355878	-	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
LXM97_RS11475 (LXM97_11475)	2355878..2356129	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LXM97_RS11480 (LXM97_11480)	2356302..2356393	-	92	Protein_2212	hypothetical protein	-
LXM97_RS11485 (LXM97_11485)	2356400..2356999	-	600	WP_000162810.1	DsbA family protein	-
LXM97_RS11490 (LXM97_11490)	2357018..2357380	-	363	WP_000819839.1	DUF4467 domain-containing protein	-
LXM97_RS11495 (LXM97_11495)	2357635..2358885	+	1251	WP_001012236.1	FemA/FemB family glycyltransferase FmhA	-
LXM97_RS11500 (LXM97_11500)	2358982..2359713	-	732	WP_000615464.1	amino acid ABC transporter ATP-binding protein	-
LXM97_RS11505 (LXM97_11505)	2359710..2360429	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T236122 WP_000113263.1 NZ_CP092447:c2355878-2355612 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T236122 NZ_LR135357:c2102125-2101784 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT236122 WP_000584499.1 NZ_CP092447:c2356129-2355878 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT236122 NZ_LR135357:c2102355-2102125 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9

Antitoxin

• AlphaFold DB: T1YB60