Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 8664291..8664985 Replicon chromosome
Accession NZ_CP092431
Organism Streptomyces deccanensis strain KCTC 19241

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag L3078_RS38235 Protein ID WP_239758685.1
Coordinates 8664629..8664985 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L3078_RS38230 Protein ID WP_239758684.1
Coordinates 8664291..8664632 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3078_RS38220 (L3078_38220) 8659996..8662323 + 2328 WP_239758680.1 DUF2786 domain-containing protein -
L3078_RS38225 (L3078_38225) 8662677..8664038 + 1362 WP_239758682.1 endonuclease domain-containing protein -
L3078_RS38230 (L3078_38230) 8664291..8664632 - 342 WP_239758684.1 XRE family transcriptional regulator Antitoxin
L3078_RS38235 (L3078_38235) 8664629..8664985 - 357 WP_239758685.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3078_RS38240 (L3078_38240) 8665563..8665835 + 273 WP_239758687.1 winged helix-turn-helix domain-containing protein -
L3078_RS38245 (L3078_38245) 8666326..8666955 - 630 WP_239758688.1 class I SAM-dependent methyltransferase -
L3078_RS38250 (L3078_38250) 8667030..8667533 - 504 WP_239758690.1 hypothetical protein -
L3078_RS38255 (L3078_38255) 8667731..8668510 + 780 WP_239758692.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-111)

Antitoxin

HigA2-like, helix-turn-helix domain

(22-102)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13131.96 Da        Isoelectric Point: 7.2034

>T236088 WP_239758685.1 NZ_CP092431:c8664985-8664629 [Streptomyces deccanensis]
MPFKIVVVEPARSWLHHLRQTDRGTLIQITQAFNVLQIEGPALGRPLVDRITGSAVPNLKELRPGSSGASEVRLLFVFDP
ERNAVILVGGDKAGNWSGWYRTAIKEAEEAYTAYREES

Download         Length: 357 bp

>T236088 NZ_LR135297:198850-199116 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12340.01 Da        Isoelectric Point: 4.9663

>AT236088 WP_239758684.1 NZ_CP092431:c8664632-8664291 [Streptomyces deccanensis]
MSVKKQSTANAVDWDDLKEEFDFSPEEKKEIEQGTAALLSEVRAYRLAEVRKRQHMTQTAVAKILGVTQGRVSAIEKGAL
SRSEVDTLAAYVEALGGKLKLVADFGDESLVLG

Download         Length: 342 bp

>AT236088 NZ_LR135297:198587-198850 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References