Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3833120..3833632 Replicon chromosome
Accession NZ_CP092430
Organism Mycolicibacter virginiensis strain DSM 100883

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MJO54_RS18610 Protein ID WP_064888350.1
Coordinates 3833120..3833377 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MJO54_RS18615 Protein ID WP_046285305.1
Coordinates 3833378..3833632 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJO54_RS18585 (MJO54_18545) 3828704..3830527 + 1824 WP_240175301.1 fatty acyl-AMP ligase -
MJO54_RS18590 (MJO54_18550) 3830544..3830975 - 432 WP_046285299.1 PIN domain-containing protein -
MJO54_RS18595 (MJO54_18555) 3830972..3831199 - 228 WP_192830613.1 CopG family transcriptional regulator -
MJO54_RS18600 (MJO54_18560) 3831266..3832768 - 1503 WP_105295625.1 hypothetical protein -
MJO54_RS18605 (MJO54_18565) 3832770..3833072 - 303 WP_046285296.1 type VII secretion target -
MJO54_RS18610 (MJO54_18570) 3833120..3833377 - 258 WP_064888350.1 Txe/YoeB family addiction module toxin Toxin
MJO54_RS18615 (MJO54_18575) 3833378..3833632 - 255 WP_046285305.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MJO54_RS18620 (MJO54_18580) 3833741..3835072 - 1332 WP_240175302.1 phosphoglucosamine mutase -
MJO54_RS18625 (MJO54_18585) 3835218..3835733 - 516 WP_275564466.1 30S ribosomal protein S9 -
MJO54_RS18630 (MJO54_18590) 3835730..3836173 - 444 WP_046285292.1 50S ribosomal protein L13 -
MJO54_RS18635 (MJO54_18595) 3836445..3836741 - 297 WP_240175303.1 WXG100 family type VII secretion target -
MJO54_RS18640 (MJO54_18600) 3836754..3837080 - 327 WP_046285290.1 WXG100 family type VII secretion target -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10329.71 Da        Isoelectric Point: 9.7990

>T236086 WP_064888350.1 NZ_CP092430:c3833377-3833120 [Mycolicibacter virginiensis]
VKLVWDESAWDDYLYWQRQDRRVLRRINQLVADIQRNGNEGIGKPEPLKRGFQGYWSRRITAEHRLVYKVVDDEVRIAQC
RLHYS

Download         Length: 258 bp

>T236086 NZ_LR135294:51953-52228 [Enterococcus faecium]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAATT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCATGCACTAACAGGAAATTATA
TAGGTACACGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCCCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9135.38 Da        Isoelectric Point: 4.8047

>AT236086 WP_046285305.1 NZ_CP092430:c3833632-3833378 [Mycolicibacter virginiensis]
MKTMSYSATRAAFAATLDSVLDDREEVIITRSGKPPVVLVALEDYEALKETAHLLQNPANARRLLGSIERLEAGEGAAHD
LLDK

Download         Length: 255 bp

>AT236086 NZ_LR135294:51694-51960 [Enterococcus faecium]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References