Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 6819267..6819790 Replicon chromosome
Accession NZ_CP092417
Organism Endozoicomonas sp. SCSIO W0465

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MJO57_RS30845 Protein ID WP_252027148.1
Coordinates 6819536..6819790 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MJO57_RS30840 Protein ID WP_252027147.1
Coordinates 6819267..6819521 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJO57_RS30810 (MJO57_30680) 6814480..6815400 - 921 WP_252021282.1 nucleotide sugar dehydrogenase -
MJO57_RS30815 (MJO57_30685) 6815583..6815906 - 324 WP_252021285.1 transposase -
MJO57_RS30820 (MJO57_30690) 6815955..6816881 + 927 WP_252021287.1 transposase -
MJO57_RS30825 (MJO57_30695) 6816931..6817611 + 681 WP_252021289.1 transposase -
MJO57_RS30830 (MJO57_30700) 6817616..6818677 - 1062 WP_252021291.1 ISNCY family transposase -
MJO57_RS30835 (MJO57_30705) 6818817..6819086 - 270 Protein_6129 UDP-glucose 6-dehydrogenase -
MJO57_RS30840 (MJO57_30710) 6819267..6819521 + 255 WP_252027147.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MJO57_RS30845 (MJO57_30715) 6819536..6819790 + 255 WP_252027148.1 Txe/YoeB family addiction module toxin Toxin
MJO57_RS30850 (MJO57_30720) 6819944..6821461 - 1518 WP_252017502.1 IS1182 family transposase -
MJO57_RS30855 (MJO57_30725) 6821533..6822375 - 843 WP_252021293.1 transposase -
MJO57_RS30860 (MJO57_30730) 6822493..6823434 + 942 WP_252021295.1 transposase -
MJO57_RS30865 (MJO57_30735) 6823639..6824151 - 513 Protein_6135 GDP-mannose 4,6-dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10230.64 Da        Isoelectric Point: 8.4867

>T236069 WP_252027148.1 NZ_CP092417:6819536-6819790 [Endozoicomonas sp. SCSIO W0465]
ITLSWAEEAWEDFQYWLDNDKPKARKLRKLIKECMRTPFEGTGKPEPLKGNFSGFWSRRIDQEHRLVYAYSNDNLFILQC
RFHY

Download         Length: 255 bp

>T236069 NZ_LR135257:52331-52588 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9539.88 Da        Isoelectric Point: 7.2017

>AT236069 WP_252027147.1 NZ_CP092417:6819267-6819521 [Endozoicomonas sp. SCSIO W0465]
MNVVSYTEMRKNLKAVLDSVVNDATHTVIHRRDAEDAVVMSKESYDSLMETLYLLSSPENARRLKSAAEQFKANKGIKRD
LPEL

Download         Length: 255 bp

>AT236069 NZ_LR135257:52069-52338 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References