236064

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3366202..3366793 Replicon chromosome
Accession NZ_CP092417
Organism Endozoicomonas sp. SCSIO W0465

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MJO57_RS14995 Protein ID WP_252026478.1
Coordinates 3366593..3366793 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MJO57_RS14990 Protein ID WP_252026476.1
Coordinates 3366202..3366489 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJO57_RS14950 (MJO57_14875) 3361371..3362078 - 708 WP_252026462.1 adenine deaminase C-terminal domain-containing protein -
MJO57_RS14955 (MJO57_14880) 3362112..3363626 - 1515 WP_252017330.1 IS66 family transposase -
MJO57_RS14960 (MJO57_14885) 3363786..3364487 - 702 WP_252026464.1 VacJ family lipoprotein -
MJO57_RS14965 (MJO57_14890) 3364788..3365063 + 276 WP_252026466.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
MJO57_RS14970 (MJO57_14895) 3365060..3365452 + 393 WP_252026468.1 type II toxin-antitoxin system VapC family toxin -
MJO57_RS14975 (MJO57_14900) 3365497..3365721 + 225 WP_252026470.1 hypothetical protein -
MJO57_RS14980 (MJO57_14905) 3365718..3365879 + 162 WP_252026472.1 PIN domain-containing protein -
MJO57_RS14985 (MJO57_14910) 3365852..3366079 + 228 WP_252026474.1 hypothetical protein -
MJO57_RS14990 (MJO57_14915) 3366202..3366489 - 288 WP_252026476.1 helix-turn-helix domain-containing protein Antitoxin
MJO57_RS14995 (MJO57_14920) 3366593..3366793 - 201 WP_252026478.1 hypothetical protein Toxin
MJO57_RS15000 (MJO57_14925) 3367224..3368204 + 981 WP_252026480.1 IS4 family transposase -
MJO57_RS15005 (MJO57_14930) 3368164..3369204 - 1041 WP_252017335.1 IS1595 family transposase -
MJO57_RS15010 (MJO57_14935) 3369281..3369586 + 306 WP_252017680.1 hypothetical protein -
MJO57_RS15015 (MJO57_14940) 3369728..3370015 - 288 WP_252026482.1 antitoxin -
MJO57_RS15020 (MJO57_14945) 3370012..3370290 - 279 WP_252026484.1 hypothetical protein -
MJO57_RS15025 (MJO57_14950) 3370611..3370895 + 285 WP_252026486.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MJO57_RS15030 (MJO57_14955) 3370882..3371262 + 381 WP_252026488.1 hypothetical protein -
MJO57_RS15035 (MJO57_14960) 3371396..3371716 + 321 WP_252026490.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-74)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7599.67 Da        Isoelectric Point: 9.5634

>T236064 WP_252026478.1 NZ_CP092417:c3366793-3366593 [Endozoicomonas sp. SCSIO W0465]
MIFIETSKFTKLLSDYLSDDEYRMLQWHLQEKPDSGDIVRGSGGVRKVRWAPEGKGKSSGVRVIYH

Download         Length: 201 bp

>T236064 NZ_LR135247:39401-40264 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10538.19 Da        Isoelectric Point: 9.8611

>AT236064 WP_252026476.1 NZ_CP092417:c3366489-3366202 [Endozoicomonas sp. SCSIO W0465]
MSKRDIGQEILDGIEEIKAFKSGEGKLKTSILSDPSPAKEIRKKLKLSQSAFAGLMGVSIRTIQDWEQGRRSPQGPAKAL
LRIAEQCPEVFQELQ

Download         Length: 288 bp

>AT236064 NZ_LR135247:39127-39399 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References