236057

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 688517..689747 Replicon chromosome
Accession NZ_CP092415
Organism Muricauda aquimarina strain SCSIO W0262

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag MJO53_RS03210 Protein ID WP_252080460.1
Coordinates 688517..689440 (-) Length 308 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag MJO53_RS03215 Protein ID WP_247043446.1
Coordinates 689433..689747 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJO53_RS03190 (MJO53_03190) 684071..685156 - 1086 WP_252080456.1 hypothetical protein -
MJO53_RS03195 (MJO53_03195) 685137..685688 - 552 WP_252080457.1 hypothetical protein -
MJO53_RS03200 (MJO53_03200) 685685..686224 - 540 WP_252080458.1 RNA polymerase sigma factor -
MJO53_RS03205 (MJO53_03205) 686710..687795 - 1086 WP_252080459.1 AraC family transcriptional regulator -
MJO53_RS03210 (MJO53_03210) 688517..689440 - 924 WP_252080460.1 HipA domain-containing protein Toxin
MJO53_RS03215 (MJO53_03215) 689433..689747 - 315 WP_247043446.1 HipA N-terminal domain-containing protein Antitoxin
MJO53_RS03220 (MJO53_03220) 689744..689959 - 216 WP_252080461.1 helix-turn-helix domain-containing protein -
MJO53_RS03225 (MJO53_03225) 690537..691544 - 1008 WP_252080462.1 inositol 2-dehydrogenase -
MJO53_RS03230 (MJO53_03230) 691560..692465 - 906 WP_252080463.1 sugar phosphate isomerase/epimerase -
MJO53_RS03235 (MJO53_03235) 692476..693951 - 1476 WP_252080464.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(52-279)

Antitoxin

HipA, N-terminal subdomain 1

(3-98)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 35342.98 Da        Isoelectric Point: 9.4988

>T236057 WP_252080460.1 NZ_CP092415:c689440-688517 [Muricauda aquimarina]
MNRCPITYEPCGTAKYSEKSLKMIAAKLTGLNDLPYTASELRREAANRAKKLSIQGVQPKLSANISVVEQEFKVVDQFGT
YIIKPQNDIFPELPENEDLTMRMAKVLGINVPFHGMVYGKDGSLSYFIKRFDRYGKGKKYATEDFAQLTGNTRDTKYRFS
MEKLVPVIEEFCTFPVVEKVEFFKRIVFCFVTGNEDMHLKNFSLITKNGKTTLAPAYDLLNSSIAIKNPEEEIALNLKGK
KSNLKASDFTDYYAKERLQLNEKTIETILQDMFKAKQKWKDLISISFLSDDMKEKYSKILEHRLKMF

Download         Length: 924 bp

>T236057 NZ_LR135239:c21692-20829 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11631.25 Da        Isoelectric Point: 4.2450

>AT236057 WP_247043446.1 NZ_CP092415:c689747-689433 [Muricauda aquimarina]
MRKAVVYTHGKRAGVLTEISPQEYMFTYDDDYSGQAISLTMPVDQKEFSFNGFPPFFEGLLPEGIMLEGLLKISKIDHND
YFSQLMATGADLVGAVTVKPMEDE

Download         Length: 315 bp

>AT236057 NZ_LR135239:c21966-21694 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References