Detailed information of TA system TA235992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 489927..490573
• Replicon: chromosome
• Accession: NZ_CP092373
• Organism: Pantoea sp. Z09

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MC269_RS02385
• Protein ID: WP_239953677.1
• Coordinates: 490223..490573 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MC269_RS02380
• Protein ID: WP_239953675.1
• Coordinates: 489927..490226 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC269_RS02365	486096..487328	-	1233	WP_081140814.1	serine/threonine transporter SstT	-
MC269_RS02370	487564..488535	-	972	WP_239953670.1	TerC family protein	-
MC269_RS02375	488790..489782	-	993	WP_239953673.1	Gfo/Idh/MocA family oxidoreductase	-
MC269_RS02380	489927..490226	-	300	WP_239953675.1	XRE family transcriptional regulator	Antitoxin
MC269_RS02385	490223..490573	-	351	WP_239953677.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MC269_RS02390	490797..492485	+	1689	WP_239953678.1	chloride channel protein	-
MC269_RS02395	492482..492985	-	504	WP_081140818.1	M48 family metallopeptidase	-
MC269_RS02400	493067..494185	+	1119	WP_239953680.1	23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13438.52 Da
• Isoelectric Point: 9.4459

>T235992 WP_239953677.1 NZ_CP092373:c490573-490223 [Pantoea sp. Z09]
MWTVLFGEIFDAWFEDQEEALQEKILADLINLRTYGPTLPRPYADTVKGSRHKNMKELRIQYAGKPVRAFFAFDPVRRAV
ILCAGDKSNDKNFYPRMIRIADDAFTAHLNNMKGKL

Nucleotide

• Length: 351 bp

>T235992 NZ_LR134531:1436965-1437270 [Pragia fontium]
ATGCTGAAAAGTAAAGAGGTACGCTTAACGCCAAAAGCGATTAGCGATCTGGAAAATATTTATGAGTATAGCCATCGAGA
ATTTGGCCAGATTAAAGCAGAACGGTATATCAGACGTATTGATGCTGCTTTGAATAAATTGGCTGATTTTCCTCGGTCAG
GCATTCACTATTTTCATTTGGCTGAAGATTTGATGGGTTATAAGGTTGAGTCTCATATCGTCTTTTATCGTGTACAGCAT
GATGTAATTTCGGTATTACGGGTGCTGCATAAATCGATGGATTATGCAGAACATATTCATCGTTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11086.81 Da
• Isoelectric Point: 5.1768

>AT235992 WP_239953675.1 NZ_CP092373:c490226-489927 [Pantoea sp. Z09]
MRTLDDAIAARSAESQQRIRDMADEMVLETGLQMMREELQLSQKNVAEAMGISQPAITQLEQRGNELKIATLKRYIEAMG
GKLSLDVELPSGKRIAFHL

Nucleotide

• Length: 300 bp

>AT235992 NZ_LR134531:1436721-1436978 [Pragia fontium]
ATGGCACGCACAATGACCATCACCCCAGGAGAAGAATTGCGCCAATTCGTTGAAGGGCTCGTGGAAGCGGGCATTTATCA
AACTAACAGTGAAGTAGTTCGTGAGGGACTTCGGATGTTACAGGAAAAATATGCGGCTTCGCAGCTGACGCTTCTGCGCC
AATTAATTGATGAAGGTGAGCAAAGCGGTGAGGCTGTGACGTGGAATAGTCAGGACTTTATACGCAGGATGAATCAATTA
AAGGATGCTGAAAAGTAA