Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4551498..4552074 | Replicon | chromosome |
| Accession | NZ_CP092289 | ||
| Organism | Marinobacter sp. M1C | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | MIH19_RS21485 | Protein ID | WP_249006800.1 |
| Coordinates | 4551796..4552074 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | graA | Uniprot ID | - |
| Locus tag | MIH19_RS21480 | Protein ID | WP_249008970.1 |
| Coordinates | 4551498..4551785 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MIH19_RS21425 (MIH19_21425) | 4546637..4546861 | + | 225 | Protein_4228 | transposase domain-containing protein | - |
| MIH19_RS21430 (MIH19_21430) | 4547019..4547336 | - | 318 | WP_249006791.1 | antibiotic biosynthesis monooxygenase | - |
| MIH19_RS21435 (MIH19_21435) | 4547450..4547776 | - | 327 | WP_249006792.1 | antibiotic biosynthesis monooxygenase | - |
| MIH19_RS21440 (MIH19_21440) | 4547870..4548190 | - | 321 | WP_249006793.1 | hypothetical protein | - |
| MIH19_RS21445 (MIH19_21445) | 4548337..4548588 | + | 252 | WP_012137510.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| MIH19_RS21450 (MIH19_21450) | 4548585..4548839 | + | 255 | WP_249006794.1 | Txe/YoeB family addiction module toxin | - |
| MIH19_RS21455 (MIH19_21455) | 4549060..4549251 | - | 192 | WP_249006795.1 | hypothetical protein | - |
| MIH19_RS21460 (MIH19_21460) | 4549345..4549569 | + | 225 | WP_249006796.1 | hypothetical protein | - |
| MIH19_RS21465 (MIH19_21465) | 4549747..4550649 | - | 903 | WP_249006797.1 | hypothetical protein | - |
| MIH19_RS21470 (MIH19_21470) | 4550753..4551055 | - | 303 | WP_249006798.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH19_RS21475 (MIH19_21475) | 4551052..4551333 | - | 282 | WP_249006799.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MIH19_RS21480 (MIH19_21480) | 4551498..4551785 | - | 288 | WP_249008970.1 | HigA family addiction module antitoxin | Antitoxin |
| MIH19_RS21485 (MIH19_21485) | 4551796..4552074 | - | 279 | WP_249006800.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MIH19_RS21490 (MIH19_21490) | 4552192..4552815 | - | 624 | WP_249006774.1 | SagB/ThcOx family dehydrogenase | - |
| MIH19_RS21495 (MIH19_21495) | 4552894..4553472 | - | 579 | WP_249006775.1 | TetR/AcrR family transcriptional regulator | - |
| MIH19_RS21500 (MIH19_21500) | 4553572..4554054 | + | 483 | WP_249018609.1 | HPP family protein | - |
| MIH19_RS21505 (MIH19_21505) | 4554366..4554908 | - | 543 | WP_249006801.1 | DinB family protein | - |
| MIH19_RS21510 (MIH19_21510) | 4554997..4555290 | - | 294 | WP_249006802.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH19_RS21515 (MIH19_21515) | 4555287..4555661 | - | 375 | WP_249006803.1 | addiction module protein | - |
| MIH19_RS21520 (MIH19_21520) | 4555857..4556324 | - | 468 | WP_249006804.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4519370..4567768 | 48398 | |
| - | inside | Integron | - | - | 4546938..4551785 | 4847 | |
| - | inside | Integron | - | - | 4555287..4568836 | 13549 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10330.85 Da Isoelectric Point: 10.3742
>T235912 WP_249006800.1 NZ_CP092289:c4552074-4551796 [Marinobacter sp. M1C]
MIRSFKHKGLAKFFKSGSIAGIQAAHAKRLRLILGRLNAASDAKDMDLPGLRLHELSGNRAGIWSVMVSGNWRVTFRFED
GDAEIVNYEDYH
MIRSFKHKGLAKFFKSGSIAGIQAAHAKRLRLILGRLNAASDAKDMDLPGLRLHELSGNRAGIWSVMVSGNWRVTFRFED
GDAEIVNYEDYH
Download Length: 279 bp
>T235912 NZ_LR134485:4543821-4544138 [Citrobacter youngae]
ATCATGGAAATTCTTCAGACCACGGTTTTCCAACGCTGGGAGCAGAACCTACGGGATCGCAGGGCCAAAACGCTCATTGC
CGCACGACTTTTTCGACTGGCGAATGGTTTAGCTGGCGATGTTAAACCTGTAGGTGAAGGCATCAGCGAAATGCGCATTT
CTTACGGTCCTGGTTACAGGATTTACTTTAAACAGCATGGCTGCCGCATCATCATTTTGCTATGTGGTGGCGATAAAAGC
TCACAAGCTAACAATATCACCCTTGCAAAAGTGCTCGCCCGTTCACTGGACTATCAGGAGACATTCCGCCATGAATAA
ATCATGGAAATTCTTCAGACCACGGTTTTCCAACGCTGGGAGCAGAACCTACGGGATCGCAGGGCCAAAACGCTCATTGC
CGCACGACTTTTTCGACTGGCGAATGGTTTAGCTGGCGATGTTAAACCTGTAGGTGAAGGCATCAGCGAAATGCGCATTT
CTTACGGTCCTGGTTACAGGATTTACTTTAAACAGCATGGCTGCCGCATCATCATTTTGCTATGTGGTGGCGATAAAAGC
TCACAAGCTAACAATATCACCCTTGCAAAAGTGCTCGCCCGTTCACTGGACTATCAGGAGACATTCCGCCATGAATAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10471.12 Da Isoelectric Point: 7.3594
>AT235912 WP_249008970.1 NZ_CP092289:c4551785-4551498 [Marinobacter sp. M1C]
MLMHNPPHPGEVLRELCLEPLNLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA
MLMHNPPHPGEVLRELCLEPLNLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA
Download Length: 288 bp
>AT235912 NZ_LR134485:4544131-4544409 [Citrobacter youngae]
ATGAATAAGCTTACTCAGTACGATCCCGCTGCTGCGCTAGTTGATGATGAAGAAATTGCTGTATTTATGGCGGATGCCCT
CGAAACAGGCGATGCAACGTACATTGCAAAAGCGTTGGGCGTGGTGGCACGCGCTAAGGGAATGGCGAACATCGCGGCAG
AAACGGGATTATCCCGCGAACAACTCTATCGCTCGTTTAGTGAGAAAGGAAACCCGACGCTGAAAACCACGCTGGCGGTG
ATGAAGGCGCTCGGTATTGGATTGACACTTAGAAAATAG
ATGAATAAGCTTACTCAGTACGATCCCGCTGCTGCGCTAGTTGATGATGAAGAAATTGCTGTATTTATGGCGGATGCCCT
CGAAACAGGCGATGCAACGTACATTGCAAAAGCGTTGGGCGTGGTGGCACGCGCTAAGGGAATGGCGAACATCGCGGCAG
AAACGGGATTATCCCGCGAACAACTCTATCGCTCGTTTAGTGAGAAAGGAAACCCGACGCTGAAAACCACGCTGGCGGTG
ATGAAGGCGCTCGGTATTGGATTGACACTTAGAAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|