Detailed information of TA system TA235905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yafN-yafO (relBE)/YafO-YafN
• Location: 2821241..2821932
• Replicon: chromosome
• Accession: NZ_CP092289
• Organism: Marinobacter sp. M1C

Toxin (Protein)

• Gene name: yafO
• Uniprot ID: -
• Locus tag: MIH19_RS13215
• Protein ID: WP_249005321.1
• Coordinates: 2821241..2821636 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: yafN
• Uniprot ID: -
• Locus tag: MIH19_RS13220
• Protein ID: WP_249005322.1
• Coordinates: 2821633..2821932 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH19_RS13200 (MIH19_13200)	2817152..2818639	-	1488	WP_249005318.1	glutamate--tRNA ligase	-
MIH19_RS13205 (MIH19_13205)	2818886..2819809	+	924	WP_249005319.1	zinc ABC transporter substrate-binding protein	-
MIH19_RS13210 (MIH19_13210)	2819893..2821086	+	1194	WP_249005320.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
MIH19_RS13215 (MIH19_13215)	2821241..2821636	-	396	WP_249005321.1	type II toxin-antitoxin system YafO family toxin	Toxin
MIH19_RS13220 (MIH19_13220)	2821633..2821932	-	300	WP_249005322.1	type I toxin-antitoxin system antitoxin YafN	Antitoxin
MIH19_RS13225 (MIH19_13225)	2822081..2822197	+	117	Protein_2589	PLP-dependent transferase	-
MIH19_RS13230 (MIH19_13230)	2822268..2823236	-	969	WP_249005323.1	HipA domain-containing protein	-
MIH19_RS13235 (MIH19_13235)	2823214..2823531	-	318	WP_249005324.1	HipA N-terminal domain-containing protein	-
MIH19_RS13240 (MIH19_13240)	2823528..2823827	-	300	WP_249005325.1	helix-turn-helix transcriptional regulator	-
MIH19_RS13245 (MIH19_13245)	2824015..2824266	-	252	WP_249005326.1	DUF2442 domain-containing protein	-
MIH19_RS13250 (MIH19_13250)	2824250..2824492	-	243	WP_249005327.1	DUF4160 domain-containing protein	-
MIH19_RS13255 (MIH19_13255)	2824555..2826147	-	1593	WP_249005328.1	MBL fold metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin YafO (28-129)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15452.72 Da
• Isoelectric Point: 7.1038

>T235905 WP_249005321.1 NZ_CP092289:c2821636-2821241 [Marinobacter sp. M1C]
VIRIFKSVTIQKLFKEQDLDDLINDFRKYKESGLCPDYFGRDVAYDHPHTPSLILQEDVRHVHLSEFGAWPVRLMQFNRT
SDRHLVYCQGAIHRECYLLITLLSPDAHEQATVSNVMRKIGEQAEIFRMKY

Nucleotide

• Length: 396 bp

>T235905 NZ_LR134485:825118-825525 [Citrobacter youngae]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCACAGTGGCTCTCTCTGCTCATTCATGGGCTGGTTGCGGT
ATTCATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGTTGGTGCTGCTCTCTCTGGTGGTGTTTGATAGCG
TACGCAGTCAGCGTCGCATTAACGCTTGTCAGGGAGAGATTAGACTGTTAATGGACGGTCGCCTGCGCTGGCAGGGGCAA
GAGTGGTCTATCGTTTGTGCACCCTGGATGATTAAAACGGGCATGATGCTGCGTTTGCGTTCAGATGCGGGAAAACGTCA
GCATTTGTGGCTGGCAGCGGACAGCATGGATGACGCTGAGTGGCGGGATTTGCGGCGGTTAATGCTGCAACAGGTAAAGC
AGGGTTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11038.53 Da
• Isoelectric Point: 4.6656

>AT235905 WP_249005322.1 NZ_CP092289:c2821932-2821633 [Marinobacter sp. M1C]
MATNAILAEKSVSISALRNNPAQYFQNEPIAVLNHNKPAGYMIGAELFEKMVQLIGDQEESRTFVGRFRPRGSELADLCK
KGADLMLETTREDMEGFSE

Nucleotide

• Length: 300 bp

>AT235905 NZ_LR134485:824871-825137 [Citrobacter youngae]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGTGAACTGGACATCTCTATCATGCCGTT
TTTCGAACATGAGTATGACAACTTAAGTAACGAAGAAAAACGCATCTTTATCCGTCTGCTGGAATGTGATGATCCAGACT
TATTTAACTGGTTGATGAATCATGGGAAACCGGCTGATGAGCAGTTGGAGCAGATGGTGCGACTCATCCAGATACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA