Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1919631..1920207 Replicon chromosome
Accession NZ_CP092289
Organism Marinobacter sp. M1C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MIH19_RS09175 Protein ID WP_249006800.1
Coordinates 1919929..1920207 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag MIH19_RS09170 Protein ID WP_249008970.1
Coordinates 1919631..1919918 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH19_RS09130 (MIH19_09130) 1914768..1915136 - 369 WP_249006422.1 IS66 family insertion sequence element accessory protein TnpB -
MIH19_RS09135 (MIH19_09135) 1915136..1915465 - 330 WP_249006423.1 IS66 family insertion sequence element accessory protein TnpB -
MIH19_RS22435 1915949..1916074 + 126 WP_283164110.1 hypothetical protein -
MIH19_RS09140 (MIH19_09140) 1916127..1916453 + 327 WP_249008565.1 hypothetical protein -
MIH19_RS09145 (MIH19_09145) 1916532..1917029 - 498 WP_249008566.1 hypothetical protein -
MIH19_RS09150 (MIH19_09150) 1917031..1917351 - 321 WP_249008567.1 hypothetical protein -
MIH19_RS09155 (MIH19_09155) 1917572..1918048 - 477 WP_249008568.1 helix-turn-helix domain-containing protein -
MIH19_RS09160 (MIH19_09160) 1918150..1918890 + 741 WP_249008569.1 SDR family oxidoreductase -
MIH19_RS09165 (MIH19_09165) 1918904..1919488 + 585 WP_249008570.1 2-hydroxychromene-2-carboxylate isomerase -
MIH19_RS09170 (MIH19_09170) 1919631..1919918 - 288 WP_249008970.1 HigA family addiction module antitoxin Antitoxin
MIH19_RS09175 (MIH19_09175) 1919929..1920207 - 279 WP_249006800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MIH19_RS09180 (MIH19_09180) 1920438..1921855 - 1418 Protein_1797 transposase -
MIH19_RS09185 (MIH19_09185) 1922042..1922542 - 501 WP_249008571.1 hypothetical protein -
MIH19_RS09190 (MIH19_09190) 1922544..1922858 - 315 WP_249008572.1 hypothetical protein -
MIH19_RS09195 (MIH19_09195) 1923069..1923704 - 636 WP_249008573.1 hypothetical protein -
MIH19_RS09200 (MIH19_09200) 1923993..1924319 - 327 WP_014870926.1 hypothetical protein -
MIH19_RS09205 (MIH19_09205) 1924441..1925121 - 681 WP_249008574.1 aspartate/glutamate racemase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1916127..1924319 8192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10330.85 Da        Isoelectric Point: 10.3742

>T235904 WP_249006800.1 NZ_CP092289:c1920207-1919929 [Marinobacter sp. M1C]
MIRSFKHKGLAKFFKSGSIAGIQAAHAKRLRLILGRLNAASDAKDMDLPGLRLHELSGNRAGIWSVMVSGNWRVTFRFED
GDAEIVNYEDYH

Download         Length: 279 bp

>T235904 NZ_LR134484:c1094744-1094481 [Gemella haemolysans]
ATGTACAAAATTGTTTTTGATGAAGCGATAAAAAAGGATTTAAAGAAATTAGATAAACAAACTTTAAAGATTTTATTTAG
TTGGATTGAAAAAAATTTGAGTAATACGGATGATCCACGCGGTATGGGAAAAGCTCTAGTAGGCAATAAAAAAGGTTATT
GGAGATATAGAATAGGGGATTATCGGTTAATAACAAGAATAGAAGATGATAGACTTATTATAATCGCTATTAATTTTAAA
CATCGAAGAGAAGTTTATAGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10471.12 Da        Isoelectric Point: 7.3594

>AT235904 WP_249008970.1 NZ_CP092289:c1919918-1919631 [Marinobacter sp. M1C]
MLMHNPPHPGEVLRELCLEPLNLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA

Download         Length: 288 bp

>AT235904 NZ_LR134484:c1094968-1094744 [Gemella haemolysans]
ATGACTACTTTAACATTAAGACTAAATAAAGAGGAAGAACAGATTTTTAATTCTATTTCTGGCTTATACGGTGGTAAACT
ATCTACTACTATTAAGCAACTTGCACTTGAGAAGATTGAGGATGAGTATGATCTTCAACTTATAAAAGATTTCGAAAGTC
GTGAGGAGAAAGGTGAAGTAACTCTAATAGAGTTTGATGATTTAAAGAAAGAGTTTGATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References