Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1912162..1912721 Replicon chromosome
Accession NZ_CP092289
Organism Marinobacter sp. M1C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MIH19_RS09120 Protein ID WP_249008564.1
Coordinates 1912455..1912721 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MIH19_RS09115 Protein ID WP_249008563.1
Coordinates 1912162..1912455 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH19_RS09080 (MIH19_09080) 1907908..1908954 + 1047 WP_249008557.1 ACP S-malonyltransferase -
MIH19_RS09085 (MIH19_09085) 1909148..1909744 - 597 WP_249008969.1 glutathione S-transferase -
MIH19_RS09090 (MIH19_09090) 1910173..1910487 - 315 WP_249008558.1 HigA family addiction module antitoxin -
MIH19_RS09095 (MIH19_09095) 1910498..1910776 - 279 WP_249008559.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH19_RS09100 (MIH19_09100) 1910968..1911354 - 387 WP_249008560.1 hypothetical protein -
MIH19_RS09105 (MIH19_09105) 1911564..1911836 + 273 WP_249008561.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MIH19_RS09110 (MIH19_09110) 1911817..1912089 + 273 WP_249008562.1 Txe/YoeB family addiction module toxin -
MIH19_RS09115 (MIH19_09115) 1912162..1912455 - 294 WP_249008563.1 HigA family addiction module antitoxin Antitoxin
MIH19_RS09120 (MIH19_09120) 1912455..1912721 - 267 WP_249008564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MIH19_RS09125 (MIH19_09125) 1913071..1914729 - 1659 WP_249006421.1 IS66 family transposase -
MIH19_RS09130 (MIH19_09130) 1914768..1915136 - 369 WP_249006422.1 IS66 family insertion sequence element accessory protein TnpB -
MIH19_RS09135 (MIH19_09135) 1915136..1915465 - 330 WP_249006423.1 IS66 family insertion sequence element accessory protein TnpB -
MIH19_RS22435 1915949..1916074 + 126 WP_283164110.1 hypothetical protein -
MIH19_RS09140 (MIH19_09140) 1916127..1916453 + 327 WP_249008565.1 hypothetical protein -
MIH19_RS09145 (MIH19_09145) 1916532..1917029 - 498 WP_249008566.1 hypothetical protein -
MIH19_RS09150 (MIH19_09150) 1917031..1917351 - 321 WP_249008567.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-88)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-84)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10380.77 Da        Isoelectric Point: 9.8340

>T235903 WP_249008564.1 NZ_CP092289:c1912721-1912455 [Marinobacter sp. M1C]
MIRSFRHKGLKRFYSSGIQSDHAKKLRMQLAALNTAISVEDIDIPGFRLHSLKGTDKGRWSIWVNGNWRMTFEFQDSNAY
ILDYEDYH

Download         Length: 267 bp

>T235903 NZ_LR134483:c1972072-1971728 [Listeria grayi]
ATGGTGAAGCGTGGCGATGTATACTACGCGGATCTTTCCCCTGTGGTCGGAAGCGAGCAGGGGGGAACAAGGCCTGTTCT
TATTATTCAAAATGATATAGGGAATCGACATAGTCCAACAGTTATCGTAGCGGCCATAACAGCGAAGATCCAGAAAGCAA
AGCTTCCCACACACGTAGAAGCAATGCGGAAAGACGGCTTCGATCGGGATTCCGTCATTTTACTGGAACAAGTGAGAACA
ATCGACAAACAGCGCCTTACAGACAAGATCACACATCTGGATGATGAATTGATGGAAAAAGTAGATCATGCTTTGGTCAT
CAGTTTAGGATTGATCGATCTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10741.29 Da        Isoelectric Point: 5.5589

>AT235903 WP_249008563.1 NZ_CP092289:c1912455-1912162 [Marinobacter sp. M1C]
MTMHNPPHPGEFIREVYLEPFGISSRQLASSLGVSPSTLSRLLKGDSGISPEMSLRLSKVLGRTPESWLAMQDMYDLWVA
RSTVNLDGIHPLDFEAA

Download         Length: 294 bp

>AT235903 NZ_LR134483:c1972356-1972078 [Listeria grayi]
GTGTTAGAAAAACTGGAATGGACAACGATGTCTATCGAACTTACGCAAGAAACAATGAGTGAATTGGATGTGCTTGCGAG
AAAACAACGTATCGAAAAGAACGAAATTATTGATCGGGCAGTGAAACAATATATTAGTCAGCAGAAAGTCCGGGATCTAC
GCGTGGAAATGGAACGCGGTTATGCAGAAATGGCGAATATCAACTTCGCGATTGCCTGCGAATGTACCCACGTAGAATCC
GAAGCCGAGGACAAAAATATTCGTGTATTAGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References