Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4550777..4551353 | Replicon | chromosome |
| Accession | NZ_CP092288 | ||
| Organism | Marinobacter sp. M2C | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | MIH17_RS21480 | Protein ID | WP_249006800.1 |
| Coordinates | 4551075..4551353 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | graA | Uniprot ID | - |
| Locus tag | MIH17_RS21475 | Protein ID | WP_249008970.1 |
| Coordinates | 4550777..4551064 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MIH17_RS21420 (MIH17_21420) | 4545916..4546140 | + | 225 | Protein_4226 | transposase domain-containing protein | - |
| MIH17_RS21425 (MIH17_21425) | 4546298..4546615 | - | 318 | WP_249006791.1 | antibiotic biosynthesis monooxygenase | - |
| MIH17_RS21430 (MIH17_21430) | 4546729..4547055 | - | 327 | WP_249006792.1 | antibiotic biosynthesis monooxygenase | - |
| MIH17_RS21435 (MIH17_21435) | 4547149..4547469 | - | 321 | WP_249006793.1 | hypothetical protein | - |
| MIH17_RS21440 (MIH17_21440) | 4547616..4547867 | + | 252 | WP_012137510.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| MIH17_RS21445 (MIH17_21445) | 4547864..4548118 | + | 255 | WP_249006794.1 | Txe/YoeB family addiction module toxin | - |
| MIH17_RS21450 (MIH17_21450) | 4548339..4548530 | - | 192 | WP_249006795.1 | hypothetical protein | - |
| MIH17_RS21455 (MIH17_21455) | 4548624..4548848 | + | 225 | WP_249006796.1 | hypothetical protein | - |
| MIH17_RS21460 (MIH17_21460) | 4549026..4549928 | - | 903 | WP_249006797.1 | hypothetical protein | - |
| MIH17_RS21465 (MIH17_21465) | 4550032..4550334 | - | 303 | WP_249006798.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH17_RS21470 (MIH17_21470) | 4550331..4550612 | - | 282 | WP_249006799.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MIH17_RS21475 (MIH17_21475) | 4550777..4551064 | - | 288 | WP_249008970.1 | HigA family addiction module antitoxin | Antitoxin |
| MIH17_RS21480 (MIH17_21480) | 4551075..4551353 | - | 279 | WP_249006800.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MIH17_RS21485 (MIH17_21485) | 4551471..4552094 | - | 624 | WP_249006774.1 | SagB/ThcOx family dehydrogenase | - |
| MIH17_RS21490 (MIH17_21490) | 4552173..4552751 | - | 579 | WP_249006775.1 | TetR/AcrR family transcriptional regulator | - |
| MIH17_RS21495 (MIH17_21495) | 4552851..4553333 | + | 483 | WP_249006776.1 | HPP family protein | - |
| MIH17_RS21500 (MIH17_21500) | 4553645..4554187 | - | 543 | WP_249006801.1 | DinB family protein | - |
| MIH17_RS21505 (MIH17_21505) | 4554276..4554569 | - | 294 | WP_249006802.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH17_RS21510 (MIH17_21510) | 4554566..4554940 | - | 375 | WP_249006803.1 | addiction module protein | - |
| MIH17_RS21515 (MIH17_21515) | 4555136..4555603 | - | 468 | WP_249006804.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4518649..4567047 | 48398 | |
| - | inside | Integron | - | - | 4546217..4551064 | 4847 | |
| - | inside | Integron | - | - | 4554566..4568115 | 13549 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10330.85 Da Isoelectric Point: 10.3742
>T235895 WP_249006800.1 NZ_CP092288:c4551353-4551075 [Marinobacter sp. M2C]
MIRSFKHKGLAKFFKSGSIAGIQAAHAKRLRLILGRLNAASDAKDMDLPGLRLHELSGNRAGIWSVMVSGNWRVTFRFED
GDAEIVNYEDYH
MIRSFKHKGLAKFFKSGSIAGIQAAHAKRLRLILGRLNAASDAKDMDLPGLRLHELSGNRAGIWSVMVSGNWRVTFRFED
GDAEIVNYEDYH
Download Length: 279 bp
>T235895 NZ_LR134479:927436-927690 [Rothia aeria]
ATGAAAACCATGTCTTACACTGAGTCTCGGGCTCGGTATGCTGAAGTACTTGATCACGTTGAAGACCACCGCGAAGAAGT
TGTCATCACTCGATCCGGGCATGAGCCTGCAGTTATTCTCTCATTGTCTGAGTACGAATCTCTTCAAGAGACTGCTTACC
TTATGCGTTCCCCGGCTAACGCACGTCGTCTTATGGAGTCTATTTCTCGTCTTGAAGCTGGTCTTGGAACTGAGCAGCAG
CTGATTGAGGAATAG
ATGAAAACCATGTCTTACACTGAGTCTCGGGCTCGGTATGCTGAAGTACTTGATCACGTTGAAGACCACCGCGAAGAAGT
TGTCATCACTCGATCCGGGCATGAGCCTGCAGTTATTCTCTCATTGTCTGAGTACGAATCTCTTCAAGAGACTGCTTACC
TTATGCGTTCCCCGGCTAACGCACGTCGTCTTATGGAGTCTATTTCTCGTCTTGAAGCTGGTCTTGGAACTGAGCAGCAG
CTGATTGAGGAATAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10471.12 Da Isoelectric Point: 7.3594
>AT235895 WP_249008970.1 NZ_CP092288:c4551064-4550777 [Marinobacter sp. M2C]
MLMHNPPHPGEVLRELCLEPLNLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA
MLMHNPPHPGEVLRELCLEPLNLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA
Download Length: 288 bp
>AT235895 NZ_LR134479:927693-927953 [Rothia aeria]
GTGAGAATCATATTTGATGATTCAGCATGGAGCGACTATCTCTGGTGGCAGGCTCAGGATCGGAAGGTTCTCAAACGTAT
TAATCTACTCATTAAAGATGTTGAGCGAAACGGTAACGAAGGCATAGGGAAGCCTGAAGCTCTCAGACACCAATTCTCAG
GTTGGTGGTCACGCAGAATTACCGATGAACACCGTCTCGTATACAAGCTTACTGACGACTCTATCGTTATAGCTTCATGC
CGATATCACTATGGAGCCTAG
GTGAGAATCATATTTGATGATTCAGCATGGAGCGACTATCTCTGGTGGCAGGCTCAGGATCGGAAGGTTCTCAAACGTAT
TAATCTACTCATTAAAGATGTTGAGCGAAACGGTAACGAAGGCATAGGGAAGCCTGAAGCTCTCAGACACCAATTCTCAG
GTTGGTGGTCACGCAGAATTACCGATGAACACCGTCTCGTATACAAGCTTACTGACGACTCTATCGTTATAGCTTCATGC
CGATATCACTATGGAGCCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|