Detailed information of TA system TA235888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yafN-yafO (relBE)/YafO-YafN
• Location: 2822922..2823613
• Replicon: chromosome
• Accession: NZ_CP092288
• Organism: Marinobacter sp. M2C

Toxin (Protein)

• Gene name: yafO
• Uniprot ID: -
• Locus tag: MIH17_RS13220
• Protein ID: WP_249005321.1
• Coordinates: 2822922..2823317 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: yafN
• Uniprot ID: -
• Locus tag: MIH17_RS13225
• Protein ID: WP_249005322.1
• Coordinates: 2823314..2823613 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH17_RS13205 (MIH17_13205)	2818833..2820320	-	1488	WP_249005318.1	glutamate--tRNA ligase	-
MIH17_RS13210 (MIH17_13210)	2820567..2821490	+	924	WP_249005319.1	zinc ABC transporter substrate-binding protein	-
MIH17_RS13215 (MIH17_13215)	2821574..2822767	+	1194	WP_249005320.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
MIH17_RS13220 (MIH17_13220)	2822922..2823317	-	396	WP_249005321.1	type II toxin-antitoxin system YafO family toxin	Toxin
MIH17_RS13225 (MIH17_13225)	2823314..2823613	-	300	WP_249005322.1	type I toxin-antitoxin system antitoxin YafN	Antitoxin
MIH17_RS13230 (MIH17_13230)	2823762..2823878	+	117	Protein_2590	PLP-dependent transferase	-
MIH17_RS13235 (MIH17_13235)	2823949..2824917	-	969	WP_249005323.1	HipA domain-containing protein	-
MIH17_RS13240 (MIH17_13240)	2824895..2825212	-	318	WP_249005324.1	HipA N-terminal domain-containing protein	-
MIH17_RS13245 (MIH17_13245)	2825209..2825508	-	300	WP_249005325.1	helix-turn-helix transcriptional regulator	-
MIH17_RS13250 (MIH17_13250)	2825696..2825947	-	252	WP_249005326.1	DUF2442 domain-containing protein	-
MIH17_RS13255 (MIH17_13255)	2825931..2826173	-	243	WP_249005327.1	DUF4160 domain-containing protein	-
MIH17_RS13260 (MIH17_13260)	2826236..2827828	-	1593	WP_249005328.1	MBL fold metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin YafO (28-129)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15452.72 Da
• Isoelectric Point: 7.1038

>T235888 WP_249005321.1 NZ_CP092288:c2823317-2822922 [Marinobacter sp. M2C]
VIRIFKSVTIQKLFKEQDLDDLINDFRKYKESGLCPDYFGRDVAYDHPHTPSLILQEDVRHVHLSEFGAWPVRLMQFNRT
SDRHLVYCQGAIHRECYLLITLLSPDAHEQATVSNVMRKIGEQAEIFRMKY

Nucleotide

• Length: 396 bp

>T235888 NZ_LR134478:c3170310-3169894 [Serratia plymuthica]
GTGAACAAGACCTATATGCTGGACACCAACATTTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCTGTGATCAAACGCCT
GGAGCAGGCGGTGCTGCGTAACCACCGCATCGTGGTCTCCGCCATCACCTACGCGGAAATGCGTTTCGGCGCGATCGGGA
AGAAGGCCTCGCCGCGCCATGCGCAACTGGTCGACGCGTTCTGCACCCGCCTCGATGCCGTGCTGGCCTGGGACCGGGCG
GCGGTGGACGCCACCACGGAAATCAAGGCTGCCCTGGCCGCGGCCGGGACGCCGATCGGCCCGAACGATACGGCGATCGC
CGGGCACGCCATCGCCGCCGGCGCCGTGCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTACCGGGCCTGAAGCAGG
AGGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11038.53 Da
• Isoelectric Point: 4.6656

>AT235888 WP_249005322.1 NZ_CP092288:c2823613-2823314 [Marinobacter sp. M2C]
MATNAILAEKSVSISALRNNPAQYFQNEPIAVLNHNKPAGYMIGAELFEKMVQLIGDQEESRTFVGRFRPRGSELADLCK
KGADLMLETTREDMEGFSE

Nucleotide

• Length: 300 bp

>AT235888 NZ_LR134478:c3170537-3170307 [Serratia plymuthica]
ATGCGCACAGTTTCTATTTTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCCTTTGCTCAGTTTG
AAAAAGCCGACGCAGATTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTGACCTGTGA