Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1921312..1921888 Replicon chromosome
Accession NZ_CP092288
Organism Marinobacter sp. M2C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MIH17_RS09180 Protein ID WP_249006800.1
Coordinates 1921610..1921888 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag MIH17_RS09175 Protein ID WP_249008970.1
Coordinates 1921312..1921599 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH17_RS09135 (MIH17_09135) 1916449..1916817 - 369 WP_249006422.1 IS66 family insertion sequence element accessory protein TnpB -
MIH17_RS09140 (MIH17_09140) 1916817..1917146 - 330 WP_249006423.1 IS66 family insertion sequence element accessory protein TnpB -
MIH17_RS22425 1917630..1917755 + 126 WP_283164110.1 hypothetical protein -
MIH17_RS09145 (MIH17_09145) 1917808..1918134 + 327 WP_249008565.1 hypothetical protein -
MIH17_RS09150 (MIH17_09150) 1918213..1918710 - 498 WP_249008566.1 hypothetical protein -
MIH17_RS09155 (MIH17_09155) 1918712..1919032 - 321 WP_249008567.1 hypothetical protein -
MIH17_RS09160 (MIH17_09160) 1919253..1919729 - 477 WP_249008568.1 helix-turn-helix domain-containing protein -
MIH17_RS09165 (MIH17_09165) 1919831..1920571 + 741 WP_249008569.1 SDR family oxidoreductase -
MIH17_RS09170 (MIH17_09170) 1920585..1921169 + 585 WP_249008570.1 2-hydroxychromene-2-carboxylate isomerase -
MIH17_RS09175 (MIH17_09175) 1921312..1921599 - 288 WP_249008970.1 HigA family addiction module antitoxin Antitoxin
MIH17_RS09180 (MIH17_09180) 1921610..1921888 - 279 WP_249006800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MIH17_RS09185 (MIH17_09185) 1922119..1923536 - 1418 Protein_1798 transposase -
MIH17_RS09190 (MIH17_09190) 1923723..1924223 - 501 WP_249008571.1 hypothetical protein -
MIH17_RS09195 (MIH17_09195) 1924225..1924539 - 315 WP_249008572.1 hypothetical protein -
MIH17_RS09200 (MIH17_09200) 1924750..1925385 - 636 WP_249008573.1 hypothetical protein -
MIH17_RS09205 (MIH17_09205) 1925674..1926000 - 327 WP_014870926.1 hypothetical protein -
MIH17_RS09210 (MIH17_09210) 1926122..1926802 - 681 WP_249008574.1 aspartate/glutamate racemase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1917808..1926000 8192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10330.85 Da        Isoelectric Point: 10.3742

>T235887 WP_249006800.1 NZ_CP092288:c1921888-1921610 [Marinobacter sp. M2C]
MIRSFKHKGLAKFFKSGSIAGIQAAHAKRLRLILGRLNAASDAKDMDLPGLRLHELSGNRAGIWSVMVSGNWRVTFRFED
GDAEIVNYEDYH

Download         Length: 279 bp

>T235887 NZ_LR134478:c3131719-3131321 [Serratia plymuthica]
ATGTTCAGCCATATGTTGGATACCAACATAGTCATTTATGTGATCAAACGTCGGCCGATTGAAGTGCTGAGCAAGTTTAA
TCAGCATGCCGGTAAAATGGTGATTTCGTCGGTGACTTACGCCGAATTGATTCATGGCGTTGAGAAAAGCGCGCGGCCCA
CAGAAAACGCCAGGGTCGTCGACGATTTTGTATCCCGACTGGAGATCCTTGATTACAGCGCCAAAGCTGCGGCGCATTAC
GGCAATATACGTGCCTCTTTGGAGCAGCAGGGGACACCAATGGGTGTTAATGATCTGCATATTGCCGGGCATGCGCGCAG
TGAGGGCTTAGTGCTAGTGACTAATAATCTGCGCGAATTTGAACGGGTCGATGGCCTGCGTCTGCAAAATTGGCTGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10471.12 Da        Isoelectric Point: 7.3594

>AT235887 WP_249008970.1 NZ_CP092288:c1921599-1921312 [Marinobacter sp. M2C]
MLMHNPPHPGEVLRELCLEPLNLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA

Download         Length: 288 bp

>AT235887 NZ_LR134478:c3131952-3131719 [Serratia plymuthica]
ATGACATTAGGGTCTGTATTTACCAATAACCGCACCCAGGCGGTACGTTTGCCCGCAGAGGTTCGTTTTCCCGATTCGGT
ATCAAAAGTCACGGTACGGGTGGTGGGAAAAGAACGGATCCTTGCGCCAGTAGAAAACACCTGGGACAGCTTTTTCTGTA
CGGATAAGCATGCCAGTGACGATTTTCTCACCGAGAGGGCCGAACAGTACCAGCCTGAGCGGGAAAGTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References