Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1913843..1914402 Replicon chromosome
Accession NZ_CP092288
Organism Marinobacter sp. M2C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MIH17_RS09125 Protein ID WP_249008564.1
Coordinates 1914136..1914402 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MIH17_RS09120 Protein ID WP_249008563.1
Coordinates 1913843..1914136 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH17_RS09085 (MIH17_09085) 1909589..1910635 + 1047 WP_249008557.1 ACP S-malonyltransferase -
MIH17_RS09090 (MIH17_09090) 1910829..1911425 - 597 WP_249008969.1 glutathione S-transferase -
MIH17_RS09095 (MIH17_09095) 1911854..1912168 - 315 WP_249008558.1 HigA family addiction module antitoxin -
MIH17_RS09100 (MIH17_09100) 1912179..1912457 - 279 WP_249008559.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH17_RS09105 (MIH17_09105) 1912649..1913035 - 387 WP_249008560.1 hypothetical protein -
MIH17_RS09110 (MIH17_09110) 1913245..1913517 + 273 WP_249008561.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MIH17_RS09115 (MIH17_09115) 1913498..1913770 + 273 WP_249008562.1 Txe/YoeB family addiction module toxin -
MIH17_RS09120 (MIH17_09120) 1913843..1914136 - 294 WP_249008563.1 HigA family addiction module antitoxin Antitoxin
MIH17_RS09125 (MIH17_09125) 1914136..1914402 - 267 WP_249008564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MIH17_RS09130 (MIH17_09130) 1914752..1916410 - 1659 WP_249006421.1 IS66 family transposase -
MIH17_RS09135 (MIH17_09135) 1916449..1916817 - 369 WP_249006422.1 IS66 family insertion sequence element accessory protein TnpB -
MIH17_RS09140 (MIH17_09140) 1916817..1917146 - 330 WP_249006423.1 IS66 family insertion sequence element accessory protein TnpB -
MIH17_RS22425 1917630..1917755 + 126 WP_283164110.1 hypothetical protein -
MIH17_RS09145 (MIH17_09145) 1917808..1918134 + 327 WP_249008565.1 hypothetical protein -
MIH17_RS09150 (MIH17_09150) 1918213..1918710 - 498 WP_249008566.1 hypothetical protein -
MIH17_RS09155 (MIH17_09155) 1918712..1919032 - 321 WP_249008567.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-88)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-84)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10380.77 Da        Isoelectric Point: 9.8340

>T235886 WP_249008564.1 NZ_CP092288:c1914402-1914136 [Marinobacter sp. M2C]
MIRSFRHKGLKRFYSSGIQSDHAKKLRMQLAALNTAISVEDIDIPGFRLHSLKGTDKGRWSIWVNGNWRMTFEFQDSNAY
ILDYEDYH

Download         Length: 267 bp

>T235886 NZ_LR134478:3090594-3090776 [Serratia plymuthica]
GTGAAAAGTGCAGAACTGATCAGACTGTTAGAACGGGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGTCACCATCAGTT
TAAACACCCGAGATCACGCCTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCAGGCACGCTGCGCCAAATCA
TGAGAGATGCCGGGCTGTGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10741.29 Da        Isoelectric Point: 5.5589

>AT235886 WP_249008563.1 NZ_CP092288:c1914136-1913843 [Marinobacter sp. M2C]
MTMHNPPHPGEFIREVYLEPFGISSRQLASSLGVSPSTLSRLLKGDSGISPEMSLRLSKVLGRTPESWLAMQDMYDLWVA
RSTVNLDGIHPLDFEAA

Download         Length: 294 bp

>AT235886 NZ_LR134478:3090806-3091219 [Serratia plymuthica]
ATGTTCTACCCTGCTTATGTACATTCAGACCATGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGCTATTT
CGCCGGCGATACCCTCGATATCGCCTTTGAAGACGCCAAAAGCGCACTGGATGCGCATTTCGAACTGCTGAGCGAAGACA
ACCAGGTCATCCCGCGCCCACAGGCCGTTTCCTTCCACCTGGCACAGGCAAGCGACACCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGCCGGGCGGAACGTATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCAGCATCCCGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAACGAATTAT
TGAAAGCCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References