Detailed information of TA system TA235878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 4514090..4515353
• Replicon: chromosome
• Accession: NZ_CP092284
• Organism: Marinobacter sp. M3C

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: MIH18_RS21220
• Protein ID: WP_283164900.1
• Coordinates: 4514523..4515353 (+)
• Length: 277 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: MIH18_RS21215
• Protein ID: WP_249005324.1
• Coordinates: 4514090..4514407 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH18_RS21185 (MIH18_21180)	4509480..4509761	+	282	Protein_4184	MBL fold metallo-hydrolase	-
MIH18_RS21190 (MIH18_21185)	4510171..4511088	+	918	WP_249013424.1	DUF4351 domain-containing protein	-
MIH18_RS21195 (MIH18_21190)	4511498..4513066	+	1569	WP_249013425.1	MBL fold metallo-hydrolase	-
MIH18_RS21200 (MIH18_21195)	4513129..4513371	+	243	WP_249005327.1	DUF4160 domain-containing protein	-
MIH18_RS21205 (MIH18_21200)	4513355..4513606	+	252	WP_249005326.1	DUF2442 domain-containing protein	-
MIH18_RS21210 (MIH18_21205)	4513794..4514093	+	300	WP_249005325.1	helix-turn-helix transcriptional regulator	-
MIH18_RS21215 (MIH18_21210)	4514090..4514407	+	318	WP_249005324.1	HipA N-terminal domain-containing protein	Antitoxin
MIH18_RS21220 (MIH18_21215)	4514523..4515353	+	831	WP_283164900.1	HipA domain-containing protein	Toxin
MIH18_RS21225 (MIH18_21220)	4515424..4515570	-	147	Protein_4192	PLP-dependent transferase	-
MIH18_RS21230 (MIH18_21225)	4515689..4515988	+	300	WP_249005322.1	type I toxin-antitoxin system antitoxin YafN	-
MIH18_RS21235 (MIH18_21230)	4515985..4516380	+	396	Protein_4194	type II toxin-antitoxin system YafO family toxin	-
MIH18_RS21240 (MIH18_21235)	4516535..4517728	-	1194	WP_249013427.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
MIH18_RS21245 (MIH18_21240)	4517812..4518735	-	924	WP_249013428.1	zinc ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (8-243)

Antitoxin

• HipA, N-terminal subdomain 1 (4-99)

Sequences

Toxin

Protein

• Length: 277 a.a.
• Molecular weight: 30719.10 Da
• Isoelectric Point: 7.5342

>T235878 WP_283164900.1 NZ_CP092284:4514523-4515353 [Marinobacter sp. M3C]
MPRQTHGFSISGVQMKCQLAVKGGKLQLVDSGGQFIMKPSPEEYPNVAENEHATLKLMARVGFEVPPCGLLKLNDGHLVF
VIRRYDRNFEDGTKYHQEDAMQALGISNADSGQKYTAASYEEVLNLAKKHGGDAVAASLFDRLAFSYLVGNDDHHLKNIS
FLHEPAFRLAPCYDVLASSLYSSAIDSPIALAMLKDGEQPKYHEEMANGYYSGSDFIEMGARAGLRSKALAGRLNRLIKN
VDQHAPEFIQSSFMPEDVKGKYKKLVEQRIKFMRVL

Nucleotide

• Length: 831 bp

>T235878 NZ_LR134478:212022-212297 [Serratia plymuthica]
ATGCTCGTCATCGAATGGAGTCGATCTGCCCGCCAGGACTTGGCGGATATACTGCTTTTCATTGCCAATGACAATCCTCG
GGCAGCCAGAAAAATGAAGGTGTTAATTTCAGAAGCAATTCTTCCTGCCGCTGAACATCCTCATATTTTTCGCCGTGGCA
GGGTTGATGGCACGCACGAAATCATTGTTCATCCCAATTATCTTCTGATCTACCAAGTGGTTGCCGATCGTATCCGGGTG
ATGCGAGTCCTGCATGCACGTCGACGCTATCCCTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 12089.98 Da
• Isoelectric Point: 5.1767

>AT235878 WP_249005324.1 NZ_CP092284:4514090-4514407 [Marinobacter sp. M3C]
MKARVRMKGRVAGILELQGTTVRFQYDKAYLQMRMPPLSLSLPLREEPYEYEGLLPYFSGLVSEGWLKRIQAKEQRIDPN
DEFSLLVHNGEDLPGAVTLELFDMS

Nucleotide

• Length: 318 bp

>AT235878 NZ_LR134478:211824-212021 [Serratia plymuthica]
ATGGTTATCTTACGCTCGCCTGTTGTCTCAGAATATGAGACACAAGAGCAGACGGAAATCTACGATCGCTGGTTTCGGGA
AAAGGTTCGGGAAGCCATGGATGATCCCCTGCCTGGCATTTCCCATGACGAGGTAATGGCCGAGATGGATGCTCTTATCG
CTGTAGCGGAAGCAAGGAAGAAAACCAAGCAGGTATAA