Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 789518..790094 Replicon chromosome
Accession NZ_CP092284
Organism Marinobacter sp. M3C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MIH18_RS03480 Protein ID WP_249013944.1
Coordinates 789518..789796 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag MIH18_RS03485 Protein ID WP_249013945.1
Coordinates 789807..790094 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH18_RS03455 (MIH18_03460) 785131..785436 + 306 WP_217632702.1 chorismate mutase -
MIH18_RS03460 (MIH18_03465) 785563..786996 + 1434 WP_249013941.1 hypothetical protein -
MIH18_RS03465 (MIH18_03470) 787674..787877 + 204 Protein_683 YnfA family protein -
MIH18_RS03470 (MIH18_03475) 788123..788827 + 705 WP_249013942.1 hypothetical protein -
MIH18_RS03475 (MIH18_03480) 788957..789415 + 459 WP_249013943.1 hypothetical protein -
MIH18_RS03480 (MIH18_03485) 789518..789796 + 279 WP_249013944.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MIH18_RS03485 (MIH18_03490) 789807..790094 + 288 WP_249013945.1 HigA family addiction module antitoxin Antitoxin
MIH18_RS03490 (MIH18_03495) 790574..791074 + 501 WP_249013946.1 hypothetical protein -
MIH18_RS03495 (MIH18_03500) 791222..791857 + 636 WP_249013947.1 hypothetical protein -
MIH18_RS03500 (MIH18_03505) 791946..792323 + 378 WP_249013948.1 hypothetical protein -
MIH18_RS03505 (MIH18_03510) 792486..794057 + 1572 WP_249013949.1 transposase -
MIH18_RS03510 (MIH18_03515) 794298..794882 + 585 WP_249013950.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 785411..813696 28285
- inside Integron - - 785131..791857 6726
- inside Integron - - 794982..796741 1759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10344.77 Da        Isoelectric Point: 10.4488

>T235867 WP_249013944.1 NZ_CP092284:789518-789796 [Marinobacter sp. M3C]
MIRSFKHKGLARFFKSGSTAGIQAAHAKRLRLILGRLNAASDAKDMDLPGLRLHELSGNRVGIWSVTVSGNWRVTFRFED
GDAEIVNYEDYH

Download         Length: 279 bp

>T235867 NZ_LR134442:2811361-2811756 [Propionibacterium australiense]
ATGACCATTTGCTATCTGGACACCTCTGCGGCACTCAAGCTCCTCATCGAGGAGGCCGAGTCCGAATCCCTGGGCAGCTG
GCTCACCGGGGAAGTCACGGATGGCATGACCCTGTGCTCTTCATTCCTCCTCCATGTCGAATTGCACTGTGCCGCGCGGC
GTCGTCACCGACTCGATGAGCAGGCGGTGGCTTCTTTGCTGGCGGGGATCGAACTCATCGACATCTCACGCGAGCACCTG
CTCGCTGCGGCACGAGACACGACGGGGCTGCGCGCGGCAGATGCGATCCATCTCGCGGTGGCCCTGGACGTTCGATCCGA
TCTTCTTCTCACGTATGACCAGGAGATGCAGAACGCGGCGCAACAGCGGGCATTGACGGTGGTGGCACCCGTATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10442.04 Da        Isoelectric Point: 6.8696

>AT235867 WP_249013945.1 NZ_CP092284:789807-790094 [Marinobacter sp. M3C]
MLMHNPPHPGEVLRELCLEPLGLSVTAAAEALGVSRKTLSALLNGKAGISPEMAIRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELNVKRLVAA

Download         Length: 288 bp

>AT235867 NZ_LR134442:2811101-2811364 [Propionibacterium australiense]
ATGACAGTGACGACGATCCCGCACCGCGAGCTGCGCAATGACAGCGCAGCGATCCTTCGCCGCGTCGAGGCCGGCGAGAG
CTTCATCGTGACGAACAACGGCCGGGCCGTTGCCGAGCTCATACCCATCACCCGTGATCGCCTGGCGCTGCTGCGCCAGC
AGGGCGCAACGCGCCCGGCAACCCCTGTGGACTTCAGCGCCCTCAGACGCATCAGGGGCCTCAGGTCCAAGGACGTACTG
GCCGATCTGCGCGGTGAGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References