Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4553273..4553849 Replicon chromosome
Accession NZ_CP092283
Organism Marinobacter sp. M4C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MIH16_RS21480 Protein ID WP_249006800.1
Coordinates 4553571..4553849 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag MIH16_RS21475 Protein ID WP_249008970.1
Coordinates 4553273..4553560 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH16_RS21420 (MIH16_21420) 4548412..4548636 + 225 Protein_4226 transposase domain-containing protein -
MIH16_RS21425 (MIH16_21425) 4548794..4549111 - 318 WP_249006791.1 antibiotic biosynthesis monooxygenase -
MIH16_RS21430 (MIH16_21430) 4549225..4549551 - 327 WP_249006792.1 antibiotic biosynthesis monooxygenase -
MIH16_RS21435 (MIH16_21435) 4549645..4549965 - 321 WP_249006793.1 hypothetical protein -
MIH16_RS21440 (MIH16_21440) 4550112..4550363 + 252 WP_012137510.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
MIH16_RS21445 (MIH16_21445) 4550360..4550614 + 255 WP_249006794.1 Txe/YoeB family addiction module toxin -
MIH16_RS21450 (MIH16_21450) 4550835..4551026 - 192 WP_249006795.1 hypothetical protein -
MIH16_RS21455 (MIH16_21455) 4551120..4551344 + 225 WP_249006796.1 hypothetical protein -
MIH16_RS21460 (MIH16_21460) 4551522..4552424 - 903 WP_249006797.1 hypothetical protein -
MIH16_RS21465 (MIH16_21465) 4552528..4552830 - 303 WP_249006798.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH16_RS21470 (MIH16_21470) 4552827..4553108 - 282 WP_249006799.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MIH16_RS21475 (MIH16_21475) 4553273..4553560 - 288 WP_249008970.1 HigA family addiction module antitoxin Antitoxin
MIH16_RS21480 (MIH16_21480) 4553571..4553849 - 279 WP_249006800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MIH16_RS21485 (MIH16_21485) 4553967..4554590 - 624 WP_249006774.1 SagB/ThcOx family dehydrogenase -
MIH16_RS21490 (MIH16_21490) 4554669..4555247 - 579 WP_249012519.1 TetR/AcrR family transcriptional regulator -
MIH16_RS21495 (MIH16_21495) 4555311..4555829 + 519 WP_249018576.1 HPP family protein -
MIH16_RS21500 (MIH16_21500) 4556141..4556683 - 543 WP_249018578.1 DinB family protein -
MIH16_RS21505 (MIH16_21505) 4556772..4557065 - 294 WP_249006802.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH16_RS21510 (MIH16_21510) 4557062..4557436 - 375 WP_249006803.1 addiction module protein -
MIH16_RS21515 (MIH16_21515) 4557632..4558099 - 468 WP_249006804.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10330.85 Da        Isoelectric Point: 10.3742

>T235864 WP_249006800.1 NZ_CP092283:c4553849-4553571 [Marinobacter sp. M4C]
MIRSFKHKGLAKFFKSGSIAGIQAAHAKRLRLILGRLNAASDAKDMDLPGLRLHELSGNRAGIWSVMVSGNWRVTFRFED
GDAEIVNYEDYH

Download         Length: 279 bp

>T235864 NZ_LR134442:1433697-1434080 [Propionibacterium australiense]
ATGTGGGTCATCGACGCATCCGCTGCGGCCGAGCTCCTTCTCGGCACCACGCAGGGGCGGGCCGTAGCGGCCACGATCGG
CGACGAGGACGTCTACGCGCCACAGCTGCTCGCCGTGGAGGTCGTCTCGGTCATGCGAGGAATGGTGAGAGGTGGGGACA
TCACCGGCACACGAGCCGAGGCCGCCCTGCACGACTTCGACGATCTCGGTGTCATCTGGGTCGACATGTCGCCCCTGATC
AGTGCCGCATGGGCGCTGCGCGACAGCGCTAGCGCCCACGACGCCATGTATGTGGCACTCGCCGAGCGGCTCGAGTGCCC
GCTGCTCACCTGCGACCGGCGCCTGGCCAAGACCTTCACGCGATGTGTCGTGCCTCAGGGGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10471.12 Da        Isoelectric Point: 7.3594

>AT235864 WP_249008970.1 NZ_CP092283:c4553560-4553273 [Marinobacter sp. M4C]
MLMHNPPHPGEVLRELCLEPLNLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA

Download         Length: 288 bp

>AT235864 NZ_LR134442:1433467-1433697 [Propionibacterium australiense]
ATGTCAACCGTGCAGATCAGGAATGTCCCCGATGAGCTGAGCCGCGAGCTCAAGGCCAGGGCAGCGCGCGAGGGACGCTC
GCTCAGCGACTATCTGCTCCGCGAGCTCGAACGTGTCGCCTCCCGTCCGTCTCGGGCCGAACTCTACGAGAGAATCCAGG
GACGCGATCCGGGCAGTGAACTGCCACCCGCGTCCGAGGTGCTTGAGCGCGAGCGCATGAGACGCCCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References