Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 2822912..2823603 Replicon chromosome
Accession NZ_CP092283
Organism Marinobacter sp. M4C

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag MIH16_RS13215 Protein ID WP_249005321.1
Coordinates 2822912..2823307 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag MIH16_RS13220 Protein ID WP_249005322.1
Coordinates 2823304..2823603 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH16_RS13200 (MIH16_13200) 2818823..2820310 - 1488 WP_249005318.1 glutamate--tRNA ligase -
MIH16_RS13205 (MIH16_13205) 2820557..2821480 + 924 WP_249005319.1 zinc ABC transporter substrate-binding protein -
MIH16_RS13210 (MIH16_13210) 2821564..2822757 + 1194 WP_249005320.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
MIH16_RS13215 (MIH16_13215) 2822912..2823307 - 396 WP_249005321.1 type II toxin-antitoxin system YafO family toxin Toxin
MIH16_RS13220 (MIH16_13220) 2823304..2823603 - 300 WP_249005322.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
MIH16_RS13225 (MIH16_13225) 2823752..2823868 + 117 Protein_2589 PLP-dependent transferase -
MIH16_RS13230 (MIH16_13230) 2823939..2824907 - 969 WP_249005323.1 HipA domain-containing protein -
MIH16_RS13235 (MIH16_13235) 2824885..2825202 - 318 WP_249005324.1 HipA N-terminal domain-containing protein -
MIH16_RS13240 (MIH16_13240) 2825199..2825498 - 300 WP_249005325.1 helix-turn-helix transcriptional regulator -
MIH16_RS13245 (MIH16_13245) 2825686..2825937 - 252 WP_249005326.1 DUF2442 domain-containing protein -
MIH16_RS13250 (MIH16_13250) 2825921..2826163 - 243 WP_249005327.1 DUF4160 domain-containing protein -
MIH16_RS13255 (MIH16_13255) 2826226..2827818 - 1593 WP_249005328.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(28-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15452.72 Da        Isoelectric Point: 7.1038

>T235857 WP_249005321.1 NZ_CP092283:c2823307-2822912 [Marinobacter sp. M4C]
VIRIFKSVTIQKLFKEQDLDDLINDFRKYKESGLCPDYFGRDVAYDHPHTPSLILQEDVRHVHLSEFGAWPVRLMQFNRT
SDRHLVYCQGAIHRECYLLITLLSPDAHEQATVSNVMRKIGEQAEIFRMKY

Download         Length: 396 bp

>T235857 NZ_LR134440:c2251556-2251302 [Neisseria animaloris]
ATGAAAAAGAAACACCAGCGGACACTTGCCTCGATATTCAGCCGCCCCGTACCCGGCAGCATCAAATGGGCGGATATTGA
AGCTCTGTTTATCGAATTGGACGCGGAAATTCAAGAGAGGGAGGGCAGCCGTATAGCGGTAATCCTTTTCGGACAAGTGA
AAGTGTTCCATAGGCCGCATCCAAGCCCTGATACGGATAAAAGCGCGGTTGCGAGCGTGCGGAAATGGTTGGAAGAAAAC
GGAGTAAAGCCATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11038.53 Da        Isoelectric Point: 4.6656

>AT235857 WP_249005322.1 NZ_CP092283:c2823603-2823304 [Marinobacter sp. M4C]
MATNAILAEKSVSISALRNNPAQYFQNEPIAVLNHNKPAGYMIGAELFEKMVQLIGDQEESRTFVGRFRPRGSELADLCK
KGADLMLETTREDMEGFSE

Download         Length: 300 bp

>AT235857 NZ_LR134440:c2251305-2250970 [Neisseria animaloris]
ATGAACAATGTAATGGAAATCAACGGCCATAAAGCCATTATTCAATACGACCCTGAAACCGAGTTGCTACGCGGCGAGTT
TATCGGCCTCAACGGCGGAGCGGATTTTTACGCCGATAACGTGGCAGACTTGCACAAAGAGGGGGCGGCAAGCCTGGCGG
TTTTTCTCGATGTGTGCAAAGAAAAAGGTATTGAGCCGTATAAACAGTATTCGGGTCGCTTCAATGTGCGGGTAAGCCCT
GAAACCCATGCGGCAGCTGCAGCTGCTGCGGCCTCTCAAAATATCAGCCTTAACGAGTGGGTAAACCGCGCCATCCGACA
ATGTGCCCATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References