Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1921302..1921878 Replicon chromosome
Accession NZ_CP092283
Organism Marinobacter sp. M4C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MIH16_RS09180 Protein ID WP_249006800.1
Coordinates 1921600..1921878 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag MIH16_RS09175 Protein ID WP_249008970.1
Coordinates 1921302..1921589 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH16_RS09135 (MIH16_09135) 1916439..1916807 - 369 WP_249006422.1 IS66 family insertion sequence element accessory protein TnpB -
MIH16_RS09140 (MIH16_09140) 1916807..1917136 - 330 WP_249006423.1 IS66 family insertion sequence element accessory protein TnpB -
MIH16_RS22430 1917620..1917745 + 126 WP_283164110.1 hypothetical protein -
MIH16_RS09145 (MIH16_09145) 1917798..1918124 + 327 WP_249008565.1 hypothetical protein -
MIH16_RS09150 (MIH16_09150) 1918203..1918700 - 498 WP_249008566.1 hypothetical protein -
MIH16_RS09155 (MIH16_09155) 1918702..1919022 - 321 WP_249008567.1 hypothetical protein -
MIH16_RS09160 (MIH16_09160) 1919243..1919719 - 477 WP_249008568.1 helix-turn-helix domain-containing protein -
MIH16_RS09165 (MIH16_09165) 1919821..1920561 + 741 WP_249008569.1 SDR family oxidoreductase -
MIH16_RS09170 (MIH16_09170) 1920575..1921159 + 585 WP_249008570.1 2-hydroxychromene-2-carboxylate isomerase -
MIH16_RS09175 (MIH16_09175) 1921302..1921589 - 288 WP_249008970.1 HigA family addiction module antitoxin Antitoxin
MIH16_RS09180 (MIH16_09180) 1921600..1921878 - 279 WP_249006800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MIH16_RS09185 (MIH16_09185) 1922109..1923526 - 1418 Protein_1798 transposase -
MIH16_RS09190 (MIH16_09190) 1923713..1924213 - 501 WP_249008571.1 hypothetical protein -
MIH16_RS09195 (MIH16_09195) 1924215..1924529 - 315 WP_249008572.1 hypothetical protein -
MIH16_RS09200 (MIH16_09200) 1924740..1925375 - 636 WP_249008573.1 hypothetical protein -
MIH16_RS09205 (MIH16_09205) 1925664..1925990 - 327 WP_014870926.1 hypothetical protein -
MIH16_RS09210 (MIH16_09210) 1926112..1926792 - 681 WP_249008574.1 aspartate/glutamate racemase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10330.85 Da        Isoelectric Point: 10.3742

>T235856 WP_249006800.1 NZ_CP092283:c1921878-1921600 [Marinobacter sp. M4C]
MIRSFKHKGLAKFFKSGSIAGIQAAHAKRLRLILGRLNAASDAKDMDLPGLRLHELSGNRAGIWSVMVSGNWRVTFRFED
GDAEIVNYEDYH

Download         Length: 279 bp

>T235856 NZ_LR134440:445062-445457 [Neisseria animaloris]
ATGCGCTATCTTTTGGATACCAACATTGTGAGCCATATCCTGCGCCGTCAGCCGAATGTGATGGCAAAATTGCAAAGCGT
GCCGATGTCTGATTTATATATTTCAGCGGTTACTCATGCCGAATTAATGTACGGCTTGGCGAAAAAACCTGATGCGGCCA
AGCTGCATCGTGCAGTGCATGAACTTTTATTGCGTATAGGCGTATTGCCGTTCGACGAGCAAGCAAGCACGCATTACGGA
AAATTTAAAGCGCAGGCAGAGCAGTCGGGTAAAAATCTGGCATCTTTAGATATGATGATTGCCGCCCATGCTTCCGCCGT
AAGCGCAGTGTTGGTCAGCAACGATGCCGCTTTCCAACAGATTGCTGATTTATCGGTAGAAGACTGGACGAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10471.12 Da        Isoelectric Point: 7.3594

>AT235856 WP_249008970.1 NZ_CP092283:c1921589-1921302 [Marinobacter sp. M4C]
MLMHNPPHPGEVLRELCLEPLNLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA

Download         Length: 288 bp

>AT235856 NZ_LR134440:444813-445058 [Neisseria animaloris]
ATGCAAACCGCCAAACTTTTTCAAAATGGCCGTAGTCAAGCCGTGCGGCTGCCTGCTGCATTCCGATTTACGGGTGATGA
AGTGTATATCCGCCGAGACGAAGCCACGGGCGATGTGATTCTGTCGCAACGTCCGGGCGACTGGCAGGGTTTTATCGCCG
CAGCATCGGAGCTTGACGAAAGCGATACCATTGAACGCAATACCTCCATACAGCAACGCGATCCGTTTGCAGACTGGCAG
GAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References