Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1913833..1914392 Replicon chromosome
Accession NZ_CP092283
Organism Marinobacter sp. M4C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MIH16_RS09125 Protein ID WP_249008564.1
Coordinates 1914126..1914392 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MIH16_RS09120 Protein ID WP_249008563.1
Coordinates 1913833..1914126 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH16_RS09085 (MIH16_09085) 1909579..1910625 + 1047 WP_249008557.1 ACP S-malonyltransferase -
MIH16_RS09090 (MIH16_09090) 1910819..1911415 - 597 WP_249008969.1 glutathione S-transferase -
MIH16_RS09095 (MIH16_09095) 1911844..1912158 - 315 WP_249008558.1 HigA family addiction module antitoxin -
MIH16_RS09100 (MIH16_09100) 1912169..1912447 - 279 WP_249008559.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH16_RS09105 (MIH16_09105) 1912639..1913025 - 387 WP_249008560.1 hypothetical protein -
MIH16_RS09110 (MIH16_09110) 1913235..1913507 + 273 WP_249008561.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MIH16_RS09115 (MIH16_09115) 1913488..1913760 + 273 WP_249008562.1 Txe/YoeB family addiction module toxin -
MIH16_RS09120 (MIH16_09120) 1913833..1914126 - 294 WP_249008563.1 HigA family addiction module antitoxin Antitoxin
MIH16_RS09125 (MIH16_09125) 1914126..1914392 - 267 WP_249008564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MIH16_RS09130 (MIH16_09130) 1914742..1916400 - 1659 WP_249018575.1 IS66 family transposase -
MIH16_RS09135 (MIH16_09135) 1916439..1916807 - 369 WP_249006422.1 IS66 family insertion sequence element accessory protein TnpB -
MIH16_RS09140 (MIH16_09140) 1916807..1917136 - 330 WP_249006423.1 IS66 family insertion sequence element accessory protein TnpB -
MIH16_RS22430 1917620..1917745 + 126 WP_283164110.1 hypothetical protein -
MIH16_RS09145 (MIH16_09145) 1917798..1918124 + 327 WP_249008565.1 hypothetical protein -
MIH16_RS09150 (MIH16_09150) 1918203..1918700 - 498 WP_249008566.1 hypothetical protein -
MIH16_RS09155 (MIH16_09155) 1918702..1919022 - 321 WP_249008567.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-88)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-84)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10380.77 Da        Isoelectric Point: 9.8340

>T235855 WP_249008564.1 NZ_CP092283:c1914392-1914126 [Marinobacter sp. M4C]
MIRSFRHKGLKRFYSSGIQSDHAKKLRMQLAALNTAISVEDIDIPGFRLHSLKGTDKGRWSIWVNGNWRMTFEFQDSNAY
ILDYEDYH

Download         Length: 267 bp

>T235855 NZ_LR134433:c145876-145586 [Legionella adelaidensis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10741.29 Da        Isoelectric Point: 5.5589

>AT235855 WP_249008563.1 NZ_CP092283:c1914126-1913833 [Marinobacter sp. M4C]
MTMHNPPHPGEFIREVYLEPFGISSRQLASSLGVSPSTLSRLLKGDSGISPEMSLRLSKVLGRTPESWLAMQDMYDLWVA
RSTVNLDGIHPLDFEAA

Download         Length: 294 bp

>AT235855 NZ_LR134433:c146129-145866 [Legionella adelaidensis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References