Detailed information of TA system TA235844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4548931..4549685
• Replicon: chromosome
• Accession: NZ_CP092258
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain 15

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A4Y6MJG6
• Locus tag: MF259_RS22035
• Protein ID: WP_000558165.1
• Coordinates: 4548931..4549242 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MF259_RS22040
• Protein ID: WP_001259009.1
• Coordinates: 4549239..4549685 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MF259_RS22005 (4544597)	4544597..4545499	+	903	WP_051129234.1	formate dehydrogenase subunit beta	-
MF259_RS22010 (4545496)	4545496..4546131	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
MF259_RS22015 (4546128)	4546128..4547057	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
MF259_RS22020 (4547095)	4547095..4547469	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	-
MF259_RS22025 (4547469)	4547469..4547711	-	243	WP_001523745.1	CopG family transcriptional regulator	-
MF259_RS22030 (4547916)	4547916..4548845	+	930	WP_001162861.1	alpha/beta hydrolase	-
MF259_RS22035 (4548931)	4548931..4549242	+	312	WP_000558165.1	type II toxin-antitoxin system HigB family toxin	Toxin
MF259_RS22040 (4549239)	4549239..4549685	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
MF259_RS22045 (4549700)	4549700..4550641	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
MF259_RS22050 (4550686)	4550686..4551123	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
MF259_RS22055 (4551120)	4551120..4551992	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MF259_RS22060 (4551986)	4551986..4552585	-	600	WP_023227076.1	glucose-1-phosphatase	-
MF259_RS22065 (4552776)	4552776..4553579	-	804	WP_000059689.1	DeoR family transcriptional regulator	-
MF259_RS22070 (4553613)	4553613..4554509	-	897	WP_023227075.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12433.34 Da
• Isoelectric Point: 8.4020

>T235844 WP_000558165.1 NZ_CP092258:4548931-4549242 [Salmonella enterica subsp. enterica serovar Indiana]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE

Nucleotide

• Length: 312 bp

>T235844 NZ_LR134406:c556626-556366 [Arachnia propionica]
ATGCGGATCTGCTGGGCCGACGAAGCGTGGGAGGACTACCTCTGGTGGCAAACCCAGGACCGCCGGACCCTCAAGAGAAT
CAACTCCCTGATCCGGGACATCGCTCGCAACGGAAATGAGGAACTGGGCAAACCGGAGGCGCTGCGATACCAACTCTCCG
GCTACTGGTCCCGGCGTATCACTGAGGAGCATCGGCTGGTCTACCGGATCACCGACACCGAGGTCCAGATTGCCGCATGC
CGGTACCACTATGGCCGCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT235844 WP_001259009.1 NZ_CP092258:4549239-4549685 [Salmonella enterica subsp. enterica serovar Indiana]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT235844 NZ_LR134406:c556885-556628 [Arachnia propionica]
GTGAAGACCATGTCGTACACCGAGTCCCGGGCCAACTACGCAGCGGTCCTCGACGAGGTCGTGAACAATCGCGAGGAGAT
CATCATCACCCGGGTGGGACACGAACCCGTCGTGATCGTCTCCCTGGAGGAGTACCAGTCCCTTCGCGAGACCGCCTACC
TGTTGCGTTCGCCCGCCAACGCCCAGCGGCTGGCCAGCGCCATGGAACAGCTCGACAGGAACGACGGCATCCCGCACGAC
CTCCTCGACGACCACTGA

Structures

Toxin

• AlphaFold DB: A0A4Y6MJG6