Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4647780..4648408 Replicon chromosome
Accession NZ_CP092184
Organism Serratia marcescens strain YHYF1

Toxin (Protein)


Gene name higB Uniprot ID A0A8G2G488
Locus tag MF265_RS22465 Protein ID WP_016930174.1
Coordinates 4647780..4648070 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MF265_RS22470 Protein ID WP_016930175.1
Coordinates 4648085..4648408 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF265_RS22455 (MF265_22455) 4644194..4646215 + 2022 WP_033639320.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
MF265_RS22460 (MF265_22460) 4646410..4647549 - 1140 WP_016930173.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
MF265_RS22465 (MF265_22465) 4647780..4648070 + 291 WP_016930174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MF265_RS22470 (MF265_22470) 4648085..4648408 + 324 WP_016930175.1 HigA family addiction module antitoxin Antitoxin
MF265_RS22475 (MF265_22475) 4648401..4648913 + 513 WP_016930176.1 M48 family metallopeptidase -
MF265_RS22480 (MF265_22480) 4648963..4649943 + 981 WP_143778467.1 Gfo/Idh/MocA family oxidoreductase -
MF265_RS22485 (MF265_22485) 4649945..4650676 + 732 WP_239043980.1 glutamine amidotransferase -
MF265_RS22490 (MF265_22490) 4650929..4651897 + 969 WP_016930179.1 TerC family protein -
MF265_RS22495 (MF265_22495) 4652160..4653395 + 1236 WP_049299890.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11645.30 Da        Isoelectric Point: 10.2782

>T235782 WP_016930174.1 NZ_CP092184:4647780-4648070 [Serratia marcescens]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

>T235782 NZ_LR134354:1104220-1104711 [Bifidobacterium longum subsp. infantis]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTTGATACCAATGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATTATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCAACTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATTGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12240.92 Da        Isoelectric Point: 6.7208

>AT235782 WP_016930175.1 NZ_CP092184:4648085-4648408 [Serratia marcescens]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILRRNITHA

Download         Length: 324 bp

>AT235782 NZ_LR134354:1103858-1104220 [Bifidobacterium longum subsp. infantis]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTATACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGCACCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATACGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References