Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3403262..3403922 Replicon chromosome
Accession NZ_CP092184
Organism Serratia marcescens strain YHYF1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MF265_RS16480 Protein ID WP_016927037.1
Coordinates 3403569..3403922 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag MF265_RS16475 Protein ID WP_016927038.1
Coordinates 3403262..3403564 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF265_RS16455 (MF265_16455) 3398867..3399781 - 915 WP_016927041.1 branched-chain amino acid ABC transporter permease -
MF265_RS16460 (MF265_16460) 3399905..3401023 - 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
MF265_RS16470 (MF265_16470) 3401628..3402836 - 1209 WP_239043671.1 aldose 1-epimerase family protein -
MF265_RS16475 (MF265_16475) 3403262..3403564 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
MF265_RS16480 (MF265_16480) 3403569..3403922 - 354 WP_016927037.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MF265_RS16485 (MF265_16485) 3404361..3405656 + 1296 WP_197766445.1 MFS transporter -
MF265_RS16490 (MF265_16490) 3405683..3406489 + 807 WP_044030853.1 substrate-binding domain-containing protein -
MF265_RS16495 (MF265_16495) 3406464..3407363 - 900 WP_239043672.1 LysR family transcriptional regulator -
MF265_RS16500 (MF265_16500) 3407468..3407833 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13433.33 Da        Isoelectric Point: 8.4803

>T235776 WP_016927037.1 NZ_CP092184:c3403922-3403569 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDGMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T235776 NZ_LR134351:2948221-2948472 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCCGTTATCAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT235776 WP_016927038.1 NZ_CP092184:c3403564-3403262 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT235776 NZ_LR134351:2948462-2948644 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References