23573

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 263325..263835 Replicon chromosome
Accession NC_012121
Organism Staphylococcus carnosus subsp. carnosus TM300

Toxin (Protein)


Gene name yoeB Uniprot ID B9DKQ4
Locus tag SCA_RS01310 Protein ID WP_012664284.1
Coordinates 263566..263835 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B9DKQ3
Locus tag SCA_RS01305 Protein ID WP_012664283.1
Coordinates 263325..263573 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCA_RS01285 259510..260022 + 513 WP_012664280.1 YwhD family protein -
SCA_RS01290 260206..260823 - 618 WP_012664281.1 LysE family transporter -
SCA_RS12740 261030..261399 - 370 Protein_248 fatty acid desaturase -
SCA_RS01300 261573..262985 + 1413 WP_012664282.1 PLP-dependent aminotransferase family protein -
SCA_RS01305 263325..263573 + 249 WP_012664283.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SCA_RS01310 263566..263835 + 270 WP_012664284.1 Txe/YoeB family addiction module toxin Toxin
SCA_RS01315 264322..265512 + 1191 WP_012664285.1 amidohydrolase -
SCA_RS01320 265673..266089 + 417 WP_012664286.1 DUF1934 family protein -
SCA_RS01325 266091..267755 + 1665 WP_012664287.1 arginine--tRNA ligase -
SCA_RS01330 267887..268789 + 903 WP_012664288.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10459.95 Da        Isoelectric Point: 10.0493

>T23573 WP_012664284.1 NC_012121:263566-263835 [Staphylococcus carnosus subsp. carnosus TM300]
MSKLNISFSPEAFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESIL
AASCKYHYQ

Download         Length: 270 bp

>T23573 NC_012121:263566-263835 [Staphylococcus carnosus subsp. carnosus TM300]
ATGAGTAAATTAAATATTTCATTTTCTCCTGAAGCATTTGAAGATTATAAAAATTGGCAAACTCAAGATAAAAAAGTTTG
GAAGAAAATCAATCAATTGATTAAAAGTATTGATCGTGATGGCATGTTAGATGGAATTGGTAAGCCAGAACGTTTAAAAG
GTGGTTTCAGTGGTTGGTATAGCAGACGTATCACACAAGATCACAGATTAGTATATAAAGTAACAAGTGAATCAATTTTA
GCTGCTTCATGCAAGTATCATTATCAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9305.30 Da        Isoelectric Point: 4.2081

>AT23573 WP_012664283.1 NC_012121:263325-263573 [Staphylococcus carnosus subsp. carnosus TM300]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Download         Length: 249 bp

>AT23573 NC_012121:263325-263573 [Staphylococcus carnosus subsp. carnosus TM300]
ATGGCTGTTGAAACATACTCAAATGCTAGAAAAAACTTTAGAAGTTTAATTAAACAAGTAAATGAAAACAGTGAAGCTAT
TACCATCACAACAAATGAAGAAAACGCCGTTTTAATGTCTGAAACTGATTATAATGCAATAATGGAGACTCTTTACTTAC
AACAAAACCCAGCTAACGCTGCACATCTCAAACGTTCAATTGAACAACTAGAAAAAGGCGATTCTGTTCAGGTAGAAATA
GATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9DKQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A380F8S2

References