Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2166484..2167224 | Replicon | chromosome |
| Accession | NZ_CP092106 | ||
| Organism | Vibrio sp. JC009 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | L3Q72_RS09650 | Protein ID | WP_275129738.1 |
| Coordinates | 2166907..2167224 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | L3Q72_RS09645 | Protein ID | WP_275129737.1 |
| Coordinates | 2166484..2166903 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3Q72_RS09625 (L3Q72_09615) | 2163336..2163536 | - | 201 | WP_275129734.1 | hypothetical protein | - |
| L3Q72_RS09635 (L3Q72_09625) | 2164205..2165902 | + | 1698 | WP_275129735.1 | methyl-accepting chemotaxis protein | - |
| L3Q72_RS09640 (L3Q72_09630) | 2165908..2166354 | - | 447 | WP_275129736.1 | cytidine/deoxycytidylate deaminase family protein | - |
| L3Q72_RS09645 (L3Q72_09635) | 2166484..2166903 | - | 420 | WP_275129737.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L3Q72_RS09650 (L3Q72_09640) | 2166907..2167224 | - | 318 | WP_275129738.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| L3Q72_RS09655 (L3Q72_09645) | 2167644..2168225 | + | 582 | WP_275129739.1 | electron transport complex subunit RsxA | - |
| L3Q72_RS09660 (L3Q72_09650) | 2168225..2168809 | + | 585 | WP_275129740.1 | electron transport complex subunit RsxB | - |
| L3Q72_RS09665 (L3Q72_09655) | 2168812..2171268 | + | 2457 | WP_275129741.1 | electron transport complex subunit RsxC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12137.02 Da Isoelectric Point: 9.3436
>T235710 WP_275129738.1 NZ_CP092106:c2167224-2166907 [Vibrio sp. JC009]
MHVIRREPFETAKALYPNCADALDATYKALEKSTAQTPEELKGLFPSLDNFKYVPKWYVIDIGGNSLRLIAFIEFHGSKC
FVKHIVTHAEYDRITEGYRSKKIKR
MHVIRREPFETAKALYPNCADALDATYKALEKSTAQTPEELKGLFPSLDNFKYVPKWYVIDIGGNSLRLIAFIEFHGSKC
FVKHIVTHAEYDRITEGYRSKKIKR
Download Length: 318 bp
>T235710 NZ_LR134333:2502631-2502734 [Klebsiella oxytoca]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTTTTTTT
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTTTTTTT
Antitoxin
Download Length: 140 a.a. Molecular weight: 16024.28 Da Isoelectric Point: 4.2894
>AT235710 WP_275129737.1 NZ_CP092106:c2166903-2166484 [Vibrio sp. JC009]
MINIQDLQQTVQQIEKNMPWLRGISNQAEYEQLIELMNELVEDYDANQTLIDLMFPVIHEYESKSEQFSEFNKAISELNS
GVAVLRVIIDQYNLTLSDFQNEIGAKSTVSMILSGKRSLTLAHIRALSERFNIPPQMFI
MINIQDLQQTVQQIEKNMPWLRGISNQAEYEQLIELMNELVEDYDANQTLIDLMFPVIHEYESKSEQFSEFNKAISELNS
GVAVLRVIIDQYNLTLSDFQNEIGAKSTVSMILSGKRSLTLAHIRALSERFNIPPQMFI
Download Length: 420 bp
>AT235710 NZ_LR134333:c2502741-2502596 [Klebsiella oxytoca]
AAAAGATAAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGT
AAAAGATAAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|