Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 1654633..1655404 | Replicon | chromosome |
| Accession | NZ_CP092106 | ||
| Organism | Vibrio sp. JC009 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | - |
| Locus tag | L3Q72_RS07600 | Protein ID | WP_275132041.1 |
| Coordinates | 1654633..1655100 (-) | Length | 156 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | - |
| Locus tag | L3Q72_RS07605 | Protein ID | WP_275132042.1 |
| Coordinates | 1655090..1655404 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3Q72_RS07560 (L3Q72_07550) | 1649763..1650521 | - | 759 | WP_275130851.1 | IS21-like element helper ATPase IstB | - |
| L3Q72_RS07565 (L3Q72_07555) | 1650511..1652007 | - | 1497 | WP_275130850.1 | IS21 family transposase | - |
| L3Q72_RS07570 (L3Q72_07560) | 1652211..1652561 | + | 351 | WP_275130849.1 | hypothetical protein | - |
| L3Q72_RS07575 (L3Q72_07565) | 1652718..1652939 | - | 222 | WP_275132037.1 | hypothetical protein | - |
| L3Q72_RS07580 (L3Q72_07570) | 1652939..1653439 | - | 501 | WP_275132038.1 | hypothetical protein | - |
| L3Q72_RS07585 (L3Q72_07575) | 1653576..1653833 | + | 258 | Protein_1461 | carboxypeptidase M32 | - |
| L3Q72_RS07590 (L3Q72_07580) | 1653871..1654161 | - | 291 | WP_275132039.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| L3Q72_RS07595 (L3Q72_07585) | 1654204..1654479 | - | 276 | WP_275132040.1 | hypothetical protein | - |
| L3Q72_RS07600 (L3Q72_07590) | 1654633..1655100 | - | 468 | WP_275132041.1 | type II toxin-antitoxin system YhaV family toxin | Toxin |
| L3Q72_RS07605 (L3Q72_07595) | 1655090..1655404 | - | 315 | WP_275132042.1 | type II toxin-antitoxin system PrlF family antitoxin | Antitoxin |
| L3Q72_RS07610 (L3Q72_07600) | 1655488..1655838 | + | 351 | Protein_1466 | hypothetical protein | - |
| L3Q72_RS07615 (L3Q72_07605) | 1655899..1656783 | - | 885 | WP_275132043.1 | LysR family transcriptional regulator | - |
| L3Q72_RS07620 (L3Q72_07610) | 1656935..1657759 | + | 825 | WP_275132044.1 | NAD(P)-dependent oxidoreductase | - |
| L3Q72_RS07625 (L3Q72_07615) | 1657937..1658305 | - | 369 | WP_275132045.1 | ATP-binding protein | - |
| L3Q72_RS07630 (L3Q72_07620) | 1658319..1658528 | - | 210 | WP_275132046.1 | PAS domain-containing protein | - |
| L3Q72_RS07635 (L3Q72_07625) | 1658582..1659061 | - | 480 | WP_275132047.1 | GNAT family protein | - |
| L3Q72_RS07640 (L3Q72_07630) | 1659383..1660390 | + | 1008 | WP_275132048.1 | AraC family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1652718..1669540 | 16822 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 156 a.a. Molecular weight: 18219.87 Da Isoelectric Point: 10.0067
>T235707 WP_275132041.1 NZ_CP092106:c1655100-1654633 [Vibrio sp. JC009]
MKINSWNCFTHSCFSEQYNELVEKVKLLKEKHPTTFQKKSATKLLFAIQKLIFEVIPTNPALPSYRHGGTAGINRHWFRA
KFFKGRFRLFFRYDHKSKTIIYGWVNDESTLRTYGSKSDAYSVFKKMLVDGTPPDAWDDLKRQSVDVSELIEDRD
MKINSWNCFTHSCFSEQYNELVEKVKLLKEKHPTTFQKKSATKLLFAIQKLIFEVIPTNPALPSYRHGGTAGINRHWFRA
KFFKGRFRLFFRYDHKSKTIIYGWVNDESTLRTYGSKSDAYSVFKKMLVDGTPPDAWDDLKRQSVDVSELIEDRD
Download Length: 468 bp
>T235707 NZ_LR134331:c2597339-2596956 [Lacticaseibacillus rhamnosus]
ATGGATGTAACAGTCAAACGCGGGGATGTATTTTTCGCCGATTTATCGCCGGTTGTCGGGTCGGAACAAGGCGGCAACCG
GCCCGTACTTATTATTCAAAACAATGTTGGTAACCATTATAGCCCCACTGTTATCGTGGCTGCCATTACCTCCAAAATCC
AAAAACCCAAAATGCCCACCCATGTCGGTTTGCGCGCCAAGCAAGACGGGGTTGAGCGTAATTCAGTCATTTTGCTTGAA
CAGATTCGTACAATTGATAAGCAACGGTTACAGGCACGCGTTACCGCTCTTTCAAGTGCCAAAATGGCAGCGGTGGATCG
GGCACTGGCGATATCGGTCGGACTCGTCAGCTTGCCTAAGCCGAAAACATATAATAAAAACTAA
ATGGATGTAACAGTCAAACGCGGGGATGTATTTTTCGCCGATTTATCGCCGGTTGTCGGGTCGGAACAAGGCGGCAACCG
GCCCGTACTTATTATTCAAAACAATGTTGGTAACCATTATAGCCCCACTGTTATCGTGGCTGCCATTACCTCCAAAATCC
AAAAACCCAAAATGCCCACCCATGTCGGTTTGCGCGCCAAGCAAGACGGGGTTGAGCGTAATTCAGTCATTTTGCTTGAA
CAGATTCGTACAATTGATAAGCAACGGTTACAGGCACGCGTTACCGCTCTTTCAAGTGCCAAAATGGCAGCGGTGGATCG
GGCACTGGCGATATCGGTCGGACTCGTCAGCTTGCCTAAGCCGAAAACATATAATAAAAACTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11362.71 Da Isoelectric Point: 4.0640
>AT235707 WP_275132042.1 NZ_CP092106:c1655404-1655090 [Vibrio sp. JC009]
MELLAVESSVTSRYQTTIPQEIRTALGLEKNDKIHYGLNERGEVVLSRVAQHVDPTVGAFLSLIDQDIKNGKSVSSLSAL
NPMGLELTAGMDVDLDSELFDDED
MELLAVESSVTSRYQTTIPQEIRTALGLEKNDKIHYGLNERGEVVLSRVAQHVDPTVGAFLSLIDQDIKNGKSVSSLSAL
NPMGLELTAGMDVDLDSELFDDED
Download Length: 315 bp
>AT235707 NZ_LR134331:c2597607-2597359 [Lacticaseibacillus rhamnosus]
ATGAAGAAGGAAACGTCAGTAACGGTCGCGCTTGATAGTGCTATCAAAGCGCGTTTGGATGCCTATTGCGAGTTGAATGA
TATGGGTGTTCAGGATGTCATTACTGAAGCAGTGGCGAAGTTTTTGCAGTCACAAGCACCTGAGATCAATCAATTGATTT
CTGGCTATGTGGCAATGGGACAAATCAATACGGAAATCAGCCATGCTTTCTCCGCCTGCGAAAGTGAGGCATACGCCCAT
ATTCGATAA
ATGAAGAAGGAAACGTCAGTAACGGTCGCGCTTGATAGTGCTATCAAAGCGCGTTTGGATGCCTATTGCGAGTTGAATGA
TATGGGTGTTCAGGATGTCATTACTGAAGCAGTGGCGAAGTTTTTGCAGTCACAAGCACCTGAGATCAATCAATTGATTT
CTGGCTATGTGGCAATGGGACAAATCAATACGGAAATCAGCCATGCTTTCTCCGCCTGCGAAAGTGAGGCATACGCCCAT
ATTCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|