Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1654633..1655404 Replicon chromosome
Accession NZ_CP092106
Organism Vibrio sp. JC009

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag L3Q72_RS07600 Protein ID WP_275132041.1
Coordinates 1654633..1655100 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag L3Q72_RS07605 Protein ID WP_275132042.1
Coordinates 1655090..1655404 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q72_RS07560 (L3Q72_07550) 1649763..1650521 - 759 WP_275130851.1 IS21-like element helper ATPase IstB -
L3Q72_RS07565 (L3Q72_07555) 1650511..1652007 - 1497 WP_275130850.1 IS21 family transposase -
L3Q72_RS07570 (L3Q72_07560) 1652211..1652561 + 351 WP_275130849.1 hypothetical protein -
L3Q72_RS07575 (L3Q72_07565) 1652718..1652939 - 222 WP_275132037.1 hypothetical protein -
L3Q72_RS07580 (L3Q72_07570) 1652939..1653439 - 501 WP_275132038.1 hypothetical protein -
L3Q72_RS07585 (L3Q72_07575) 1653576..1653833 + 258 Protein_1461 carboxypeptidase M32 -
L3Q72_RS07590 (L3Q72_07580) 1653871..1654161 - 291 WP_275132039.1 type II toxin-antitoxin system RelE/ParE family toxin -
L3Q72_RS07595 (L3Q72_07585) 1654204..1654479 - 276 WP_275132040.1 hypothetical protein -
L3Q72_RS07600 (L3Q72_07590) 1654633..1655100 - 468 WP_275132041.1 type II toxin-antitoxin system YhaV family toxin Toxin
L3Q72_RS07605 (L3Q72_07595) 1655090..1655404 - 315 WP_275132042.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
L3Q72_RS07610 (L3Q72_07600) 1655488..1655838 + 351 Protein_1466 hypothetical protein -
L3Q72_RS07615 (L3Q72_07605) 1655899..1656783 - 885 WP_275132043.1 LysR family transcriptional regulator -
L3Q72_RS07620 (L3Q72_07610) 1656935..1657759 + 825 WP_275132044.1 NAD(P)-dependent oxidoreductase -
L3Q72_RS07625 (L3Q72_07615) 1657937..1658305 - 369 WP_275132045.1 ATP-binding protein -
L3Q72_RS07630 (L3Q72_07620) 1658319..1658528 - 210 WP_275132046.1 PAS domain-containing protein -
L3Q72_RS07635 (L3Q72_07625) 1658582..1659061 - 480 WP_275132047.1 GNAT family protein -
L3Q72_RS07640 (L3Q72_07630) 1659383..1660390 + 1008 WP_275132048.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1652718..1669540 16822


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(9-143)

Antitoxin

PrlF antitoxin

(7-102)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 18219.87 Da        Isoelectric Point: 10.0067

>T235707 WP_275132041.1 NZ_CP092106:c1655100-1654633 [Vibrio sp. JC009]
MKINSWNCFTHSCFSEQYNELVEKVKLLKEKHPTTFQKKSATKLLFAIQKLIFEVIPTNPALPSYRHGGTAGINRHWFRA
KFFKGRFRLFFRYDHKSKTIIYGWVNDESTLRTYGSKSDAYSVFKKMLVDGTPPDAWDDLKRQSVDVSELIEDRD

Download         Length: 468 bp

>T235707 NZ_LR134331:c2597339-2596956 [Lacticaseibacillus rhamnosus]
ATGGATGTAACAGTCAAACGCGGGGATGTATTTTTCGCCGATTTATCGCCGGTTGTCGGGTCGGAACAAGGCGGCAACCG
GCCCGTACTTATTATTCAAAACAATGTTGGTAACCATTATAGCCCCACTGTTATCGTGGCTGCCATTACCTCCAAAATCC
AAAAACCCAAAATGCCCACCCATGTCGGTTTGCGCGCCAAGCAAGACGGGGTTGAGCGTAATTCAGTCATTTTGCTTGAA
CAGATTCGTACAATTGATAAGCAACGGTTACAGGCACGCGTTACCGCTCTTTCAAGTGCCAAAATGGCAGCGGTGGATCG
GGCACTGGCGATATCGGTCGGACTCGTCAGCTTGCCTAAGCCGAAAACATATAATAAAAACTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11362.71 Da        Isoelectric Point: 4.0640

>AT235707 WP_275132042.1 NZ_CP092106:c1655404-1655090 [Vibrio sp. JC009]
MELLAVESSVTSRYQTTIPQEIRTALGLEKNDKIHYGLNERGEVVLSRVAQHVDPTVGAFLSLIDQDIKNGKSVSSLSAL
NPMGLELTAGMDVDLDSELFDDED

Download         Length: 315 bp

>AT235707 NZ_LR134331:c2597607-2597359 [Lacticaseibacillus rhamnosus]
ATGAAGAAGGAAACGTCAGTAACGGTCGCGCTTGATAGTGCTATCAAAGCGCGTTTGGATGCCTATTGCGAGTTGAATGA
TATGGGTGTTCAGGATGTCATTACTGAAGCAGTGGCGAAGTTTTTGCAGTCACAAGCACCTGAGATCAATCAATTGATTT
CTGGCTATGTGGCAATGGGACAAATCAATACGGAAATCAGCCATGCTTTCTCCGCCTGCGAAAGTGAGGCATACGCCCAT
ATTCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References