Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 814574..815167 Replicon chromosome
Accession NC_012108
Organism Desulfobacterium autotrophicum HRM2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HRM2_RS03525 Protein ID WP_041273026.1
Coordinates 814574..814855 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRM2_RS03530 Protein ID WP_012663088.1
Coordinates 814868..815167 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRM2_RS03505 809726..810664 + 939 WP_012663083.1 bile acid:sodium symporter -
HRM2_RS03510 810719..811408 - 690 WP_041273024.1 queuosine precursor transporter -
HRM2_RS03515 811567..813141 - 1575 WP_012663085.1 urocanate hydratase -
HRM2_RS03520 813634..814065 + 432 WP_012663086.1 PaaI family thioesterase -
HRM2_RS03525 814574..814855 + 282 WP_041273026.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRM2_RS03530 814868..815167 + 300 WP_012663088.1 HigA family addiction module antidote protein Antitoxin
HRM2_RS03535 815364..816017 + 654 WP_012663089.1 cold shock and DUF1294 domain-containing protein -
HRM2_RS03540 816356..816586 + 231 WP_041273027.1 hypothetical protein -
HRM2_RS03550 816973..818391 + 1419 WP_012663090.1 dihydrolipoyl dehydrogenase -
HRM2_RS03555 818455..818754 + 300 WP_012663091.1 hypothetical protein -
HRM2_RS03560 819188..819652 + 465 WP_041273029.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-93)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11047.89 Da        Isoelectric Point: 10.2934

>T23568 WP_041273026.1 NC_012108:814574-814855 [Desulfobacterium autotrophicum HRM2]
MIKDFKCKETKSIFNGLFSKKLPQDIQRLAERKLIMLHRATEINDLRVPPANRLETLSGNRMGQHSIRINKKWRICFEWK
EDGVHSVEIVDYH

Download         Length: 282 bp

>T23568 NC_012108:814574-814855 [Desulfobacterium autotrophicum HRM2]
ATGATAAAAGACTTTAAATGCAAAGAAACCAAATCTATATTTAATGGCCTTTTTTCTAAAAAATTGCCACAGGATATACA
AAGGCTGGCTGAAAGGAAGTTAATCATGCTTCATAGAGCAACAGAAATAAATGATCTTAGAGTGCCGCCTGCAAATCGGC
TGGAAACGCTCAGTGGCAATCGGATGGGACAACACAGCATACGTATAAATAAAAAATGGCGAATTTGTTTTGAATGGAAA
GAGGATGGCGTACATAGTGTTGAGATCGTTGATTATCATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11322.17 Da        Isoelectric Point: 7.2770

>AT23568 WP_012663088.1 NC_012108:814868-815167 [Desulfobacterium autotrophicum HRM2]
MRDFPPTHPGEILLEEFLKPMGISQYRIAKDIGVPAMRINKIVRCERGISADTALRLAHYFGMSVDFWTGIQVHYDTEIA
KMKLGDRLEREVKTFDPAA

Download         Length: 300 bp

>AT23568 NC_012108:814868-815167 [Desulfobacterium autotrophicum HRM2]
ATGAGAGATTTTCCCCCTACACACCCTGGTGAAATATTACTTGAAGAATTCTTAAAACCAATGGGTATAAGCCAATATCG
GATTGCTAAGGATATAGGCGTTCCTGCTATGCGGATAAATAAAATTGTTCGGTGTGAAAGAGGAATCAGTGCGGATACTG
CTTTAAGATTGGCGCATTATTTTGGAATGTCTGTTGATTTCTGGACGGGAATTCAGGTTCACTATGATACTGAAATAGCC
AAAATGAAATTAGGAGACAGGTTGGAAAGGGAGGTCAAAACATTTGATCCTGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References