Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2418162..2418679 Replicon chromosome
Accession NZ_CP092072
Organism Staphylococcus argenteus strain 1710042798

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7U7PWL3
Locus tag MCF40_RS11645 Protein ID WP_031787172.1
Coordinates 2418162..2418428 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7U7PWU0
Locus tag MCF40_RS11650 Protein ID WP_031787173.1
Coordinates 2418428..2418679 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCF40_RS11620 (2413592) 2413592..2414128 - 537 WP_031787169.1 GNAT family N-acetyltransferase -
MCF40_RS11625 (2414361) 2414361..2415185 - 825 WP_000572040.1 formate/nitrite transporter family protein -
MCF40_RS11630 (2415402) 2415402..2415587 - 186 WP_000230291.1 hypothetical protein -
MCF40_RS11635 (2415671) 2415671..2416138 - 468 WP_031787170.1 SRPBCC domain-containing protein -
MCF40_RS11640 (2416321) 2416321..2417865 - 1545 WP_031787171.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MCF40_RS11645 (2418162) 2418162..2418428 - 267 WP_031787172.1 Txe/YoeB family addiction module toxin Toxin
MCF40_RS11650 (2418428) 2418428..2418679 - 252 WP_031787173.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MCF40_RS11655 (2418951) 2418951..2419550 - 600 WP_000162802.1 DsbA family protein -
MCF40_RS11660 (2419570) 2419570..2419932 - 363 WP_031787174.1 DUF4467 domain-containing protein -
MCF40_RS11665 (2420186) 2420186..2421436 + 1251 WP_031787175.1 aminoacyltransferase -
MCF40_RS11670 (2421531) 2421531..2422262 - 732 WP_000615469.1 amino acid ABC transporter ATP-binding protein -
MCF40_RS11675 (2422259) 2422259..2422978 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10511.99 Da        Isoelectric Point: 9.7791

>T235649 WP_031787172.1 NZ_CP092072:c2418428-2418162 [Staphylococcus argenteus]
MARLNITFSPQAFEDYEYFQQNDKKMVKKINELLKSIDRNGALQGIGKPEKLKSNLFGYYSRRINHEHRLVYTVDDNHIK
IASCRYHY

Download         Length: 267 bp

>T235649 NZ_LR134315:2580664-2580771 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9395.56 Da        Isoelectric Point: 4.3558

>AT235649 WP_031787173.1 NZ_CP092072:c2418679-2418428 [Staphylococcus argenteus]
MIVKNYSYARQNLKTLMTKVNDDSDVVTVTSTDDKNVVIMSEADYNSIIETLYLQQNPNNAEHLAQSIADLERGKMVTKE
IDV

Download         Length: 252 bp

>AT235649 NZ_LR134315:c2580614-2580551 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PWL3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7PWU0

References