Detailed information of TA system TA235645

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1984851..1985158
• Replicon: chromosome
• Accession: NZ_CP092072
• Organism: Staphylococcus argenteus strain 1710042798

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MCF40_RS09380
• Protein ID: WP_011447039.1
• Coordinates: 1984982..1985158 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1984851..1984990 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MCF40_RS09340 (1980417)	1980417..1980596	+	180	WP_000669789.1	hypothetical protein	-
MCF40_RS09345 (1980907)	1980907..1981167	+	261	WP_001791826.1	hypothetical protein	-
MCF40_RS09350 (1981220)	1981220..1981570	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
MCF40_RS09355 (1982081)	1982081..1982416	-	336	Protein_1802	SH3 domain-containing protein	-
MCF40_RS09360 (1983067)	1983067..1983558	-	492	WP_000920035.1	staphylokinase	-
MCF40_RS09365 (1983749)	1983749..1984504	-	756	WP_000861030.1	CHAP domain-containing protein	-
MCF40_RS09370 (1984516)	1984516..1984770	-	255	WP_000611512.1	phage holin	-
MCF40_RS09375 (1984822)	1984822..1984929	+	108	WP_001791821.1	hypothetical protein	-
- (1984851)	1984851..1984990	+	140	NuclAT_0	-	Antitoxin
- (1984851)	1984851..1984990	+	140	NuclAT_0	-	Antitoxin
- (1984851)	1984851..1984990	+	140	NuclAT_0	-	Antitoxin
- (1984851)	1984851..1984990	+	140	NuclAT_0	-	Antitoxin
MCF40_RS09380 (1984982)	1984982..1985158	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
MCF40_RS09385 (1985308)	1985308..1985604	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
MCF40_RS09390 (1985662)	1985662..1985949	-	288	WP_001040256.1	hypothetical protein	-
MCF40_RS09395 (1985996)	1985996..1986148	-	153	WP_001153681.1	hypothetical protein	-
MCF40_RS09400 (1986138)	1986138..1989923	-	3786	WP_031788239.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / scn / sak / hlb / groEL	1960306..2035158	74852

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T235645 WP_011447039.1 NZ_CP092072:c1985158-1984982 [Staphylococcus argenteus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T235645 NZ_LR134315:2200116-2200403 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGTTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT235645 NZ_CP092072:1984851-1984990 [Staphylococcus argenteus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin