Detailed information of TA system TA235616

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2392940..2393124
• Replicon: chromosome
• Accession: NZ_CP092055
• Organism: Staphylococcus aureus strain USA600

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: AH5611_RS11850
• Protein ID: WP_000482647.1
• Coordinates: 2393017..2393124 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2392940..2393000 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AH5611_RS11835	2388526..2388693	-	168	WP_031785511.1	hypothetical protein	-
AH5611_RS11840	2388924..2390657	-	1734	WP_000488492.1	ABC transporter ATP-binding protein	-
AH5611_RS11845	2390706..2392445	-	1740	WP_001064831.1	ABC transporter ATP-binding protein	-
-	2392940..2393000	+	61	-	-	Antitoxin
AH5611_RS11850	2393017..2393124	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
AH5611_RS11855	2393258..2393644	-	387	WP_000779354.1	flippase GtxA	-
AH5611_RS11860	2393912..2395054	+	1143	WP_001176860.1	glycerate kinase	-
AH5611_RS11865	2395114..2395773	+	660	WP_000831298.1	membrane protein	-
AH5611_RS11870	2395953..2397164	+	1212	WP_001191975.1	multidrug effflux MFS transporter	-
AH5611_RS11875	2397287..2397760	-	474	WP_000456491.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T235616 WP_000482647.1 NZ_CP092055:c2393124-2393017 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T235616 NZ_LR134311:c3727789-3727421 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCTCCGGCGGCGAAGCCCTGTCCGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTTTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGCGATGAAACCGTTATAAAGGAGCATATTG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAGAAATATGAGTTAGTTCGTATTGATCGCAATGGATTT
ACCTCTCAGGTACAAGCACCATATTTGACTGCGACAGACATTCTTCAAGCCAGGAAAGCGTGCGGGTTGATGAGCCGGTG
TTCTTACAGAGATGTAAGTAATATTGTTCTTAGCCGATCACGGTTGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT235616 NZ_CP092055:2392940-2393000 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin