Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 2517822..2518345 | Replicon | chromosome |
Accession | NZ_CP092052 | ||
Organism | Staphylococcus aureus strain USA300 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | X5DYX7 |
Locus tag | AH5667_RS12670 | Protein ID | WP_000074048.1 |
Coordinates | 2517822..2518088 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | W8TQT5 |
Locus tag | AH5667_RS12675 | Protein ID | WP_000587616.1 |
Coordinates | 2518088..2518345 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AH5667_RS12650 (2513129) | 2513129..2514316 | - | 1188 | WP_000026194.1 | MFS transporter | - |
AH5667_RS12655 (2514712) | 2514712..2515488 | - | 777 | WP_000072147.1 | iron export ABC transporter permease subunit FetB | - |
AH5667_RS12660 (2515481) | 2515481..2516143 | - | 663 | WP_000923520.1 | ATP-binding cassette domain-containing protein | - |
AH5667_RS12665 (2516391) | 2516391..2517467 | - | 1077 | WP_001076671.1 | M42 family metallopeptidase | - |
AH5667_RS12670 (2517822) | 2517822..2518088 | - | 267 | WP_000074048.1 | Txe/YoeB family addiction module toxin | Toxin |
AH5667_RS12675 (2518088) | 2518088..2518345 | - | 258 | WP_000587616.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
AH5667_RS12680 (2518451) | 2518451..2518645 | - | 195 | WP_001790145.1 | hypothetical protein | - |
AH5667_RS12685 (2518704) | 2518704..2519159 | + | 456 | WP_238752648.1 | DUF1307 domain-containing protein | - |
AH5667_RS12690 (2519327) | 2519327..2520904 | - | 1578 | WP_000143503.1 | FMN-binding glutamate synthase family protein | - |
AH5667_RS12695 (2521099) | 2521099..2521848 | + | 750 | WP_000072444.1 | CPBP family lipoprotein N-acylation protein LnsB | - |
AH5667_RS12700 (2522072) | 2522072..2523265 | - | 1194 | WP_000675401.1 | MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10648.23 Da Isoelectric Point: 10.1384
>T235609 WP_000074048.1 NZ_CP092052:c2518088-2517822 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD
Download Length: 267 bp
>T235609 NZ_LR134311:2089380-2089483 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 86 a.a. Molecular weight: 9774.73 Da Isoelectric Point: 4.1353
>AT235609 WP_000587616.1 NZ_CP092052:c2518345-2518088 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL
Download Length: 258 bp
>AT235609 NZ_LR134311:c2089521-2089250 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCTTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCTTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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