235609

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2517822..2518345 Replicon chromosome
Accession NZ_CP092052
Organism Staphylococcus aureus strain USA300

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag AH5667_RS12670 Protein ID WP_000074048.1
Coordinates 2517822..2518088 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag AH5667_RS12675 Protein ID WP_000587616.1
Coordinates 2518088..2518345 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH5667_RS12650 (2513129) 2513129..2514316 - 1188 WP_000026194.1 MFS transporter -
AH5667_RS12655 (2514712) 2514712..2515488 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
AH5667_RS12660 (2515481) 2515481..2516143 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
AH5667_RS12665 (2516391) 2516391..2517467 - 1077 WP_001076671.1 M42 family metallopeptidase -
AH5667_RS12670 (2517822) 2517822..2518088 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
AH5667_RS12675 (2518088) 2518088..2518345 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AH5667_RS12680 (2518451) 2518451..2518645 - 195 WP_001790145.1 hypothetical protein -
AH5667_RS12685 (2518704) 2518704..2519159 + 456 WP_238752648.1 DUF1307 domain-containing protein -
AH5667_RS12690 (2519327) 2519327..2520904 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
AH5667_RS12695 (2521099) 2521099..2521848 + 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
AH5667_RS12700 (2522072) 2522072..2523265 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T235609 WP_000074048.1 NZ_CP092052:c2518088-2517822 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T235609 NZ_LR134311:2089380-2089483 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT235609 WP_000587616.1 NZ_CP092052:c2518345-2518088 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT235609 NZ_LR134311:c2089521-2089250 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCTTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z


Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References