Detailed information of TA system TA235607

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2486331..2486515
• Replicon: chromosome
• Accession: NZ_CP092052
• Organism: Staphylococcus aureus strain USA300

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: AH5667_RS12530
• Protein ID: WP_000482650.1
• Coordinates: 2486408..2486515 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2486331..2486391 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AH5667_RS12515	2481861..2482028	-	168	WP_001790576.1	hypothetical protein	-
AH5667_RS12520	2482259..2483992	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
AH5667_RS12525	2484017..2485780	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	2486331..2486391	+	61	-	-	Antitoxin
AH5667_RS12530	2486408..2486515	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
AH5667_RS12535	2486649..2487035	-	387	WP_000779358.1	flippase GtxA	-
AH5667_RS12540	2487303..2488445	+	1143	WP_001176863.1	glycerate kinase	-
AH5667_RS12545	2488505..2489164	+	660	WP_000831298.1	membrane protein	-
AH5667_RS12550	2489337..2490548	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
AH5667_RS12555	2490671..2491144	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T235607 WP_000482650.1 NZ_CP092052:c2486515-2486408 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T235607 NZ_LR134311:1897371-1897622 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT235607 NZ_CP092052:2486331-2486391 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin