235606

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2460983..2461500 Replicon chromosome
Accession NZ_CP092052
Organism Staphylococcus aureus strain USA300

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag AH5667_RS12395 Protein ID WP_000113262.1
Coordinates 2460983..2461249 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag AH5667_RS12400 Protein ID WP_000584502.1
Coordinates 2461249..2461500 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH5667_RS12365 (2456409) 2456409..2456945 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
AH5667_RS12370 (2457178) 2457178..2458002 - 825 WP_000572040.1 formate/nitrite transporter family protein -
AH5667_RS12375 (2458219) 2458219..2458401 - 183 WP_000230294.1 hypothetical protein -
AH5667_RS12380 (2458485) 2458485..2458952 - 468 WP_000153344.1 SRPBCC domain-containing protein -
AH5667_RS12385 (2459138) 2459138..2460688 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
AH5667_RS12390 (2460877) 2460877..2460948 - 72 Protein_2399 hypothetical protein -
AH5667_RS12395 (2460983) 2460983..2461249 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
AH5667_RS12400 (2461249) 2461249..2461500 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AH5667_RS12405 (2461665) 2461665..2461766 - 102 WP_001791744.1 hypothetical protein -
AH5667_RS12410 (2461773) 2461773..2462372 - 600 WP_000162813.1 DsbA family protein -
AH5667_RS12415 (2462391) 2462391..2462750 - 360 WP_000819847.1 DUF4467 domain-containing protein -
AH5667_RS12420 (2463005) 2463005..2464255 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
AH5667_RS12425 (2464352) 2464352..2465083 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
AH5667_RS12430 (2465080) 2465080..2465799 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T235606 WP_000113262.1 NZ_CP092052:c2461249-2460983 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T235606 NZ_LR134311:1425090-1425488 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT235606 WP_000584502.1 NZ_CP092052:c2461500-2461249 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT235606 NZ_LR134311:1424863-1425090 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References